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https://hdl.handle.net/11499/30163
Title: | Risk assessment and survival of patients with pulmonary hypertension: Multicenter experience in Turkey | Authors: | Yaylalı, Yalın Tolga Başarıcı, I. Avcı, B.K. Meriç, M. Sinan, Ü.Y. Şenol, Hande Küçükoğlu, M.S. |
Keywords: | Chronic thromboembolic pulmonary hypertension Pulmonary arterial hypertension Pulmonary arterial hypertension subsets Risk assessment Survival amino terminal pro brain natriuretic peptide adult Article cardiac index chronic thromboembolic pulmonary hypertension cohort analysis congenital heart disease connective tissue disease diabetes mellitus female follow up heart catheterization heart right atrium pressure human hypertension lung vascular resistance lung wedge pressure major clinical study male middle aged mortality multicenter study obesity oxygen saturation pericardial effusion pulmonary hypertension retrospective study risk assessment six minute walk test survival rate Turkey (republic) World Health Organization adolescent aged chronic disease clinical trial complication congenital heart malformation diagnostic imaging echocardiography lung embolism turkey (bird) very elderly young adult Adolescent Adult Aged Aged, 80 and over Chronic Disease Cohort Studies Connective Tissue Diseases Echocardiography Female Follow-Up Studies Heart Defects, Congenital Humans Hypertension, Pulmonary Male Middle Aged Pulmonary Embolism Risk Assessment Survival Rate Turkey Young Adult |
Publisher: | Turkish Society of Cardiology | Abstract: | Objective: Risk stratification continues to evolve in pulmonary arterial hypertension (PAH). Our aim was to further confirm the risk assessment strategy in our cohort and to determine the most reliable model. Methods: We enrolled incident patients with idiopathic PAH (IPAH), heritable, drug-induced, congenital heart disease (CHD), connective tissue diseases (CTD) subsets, and chronic thromboembolic pulmonary hypertension (CTEPH) from January 2008 to February 2018. Data from the baseline and subsequent follow-ups within 1 year of diagnosis were included. An abbreviated risk assessment strategy was applied using the following variables: functional class (FC), 6-minute walk distance (6 MWD), N-terminal pro-brain natriuretic peptide (NT-proBNP) or BNP, right atrial (RA) area, pericardial effusion, the mean RA pressure, cardiac index, and mixed venous oxygen saturation. Three different methods were applied to categorize patients. Results: A total of 189 subjects (46±17 years, 23% male) were included. Sixty-one patients had died. The survival differed significantly between the risk groups both at diagnosis and during the follow-up. Patients with a low-risk profile had a better survival rate. An abbreviated risk assessment tool predicted mortality at early follow-up in the entire group and CHD, CTD subsets, and CTEPH, separately. An overall mortality among risk categories was significantly different according to each categorization method. The most reliable model comprised FC, 6 MWD, NT pro-BNP/BNP, and the RA area at the follow-up. Conclusion: The abbreviated risk assessment tool may be valid for the PAH subsets and CTEPH. Echocardiographic variables do matter. A model comprising FC, 6 MWD, NT pro-BNP/BNP, and the RA area at the follow-up could be useful for better prognostication. (Anatol J Cardiol 2019; 21: 322-30). © Copyright 2019 by Turkish Society of Cardiology. | URI: | https://hdl.handle.net/11499/30163 https://doi.org/10.14744/AnatolJCardiol.2019.53498 |
ISSN: | 2149-2263 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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