Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/30208
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dc.contributor.authorBecerir, T.-
dc.contributor.authorYüksel, Selçuk-
dc.contributor.authorEvrengül, Havva-
dc.contributor.authorErgin, Ahmet-
dc.contributor.authorEnli, Yaşar-
dc.date.accessioned2020-06-08T12:11:46Z
dc.date.available2020-06-08T12:11:46Z
dc.date.issued2019-
dc.identifier.issn0301-1623-
dc.identifier.urihttps://hdl.handle.net/11499/30208-
dc.identifier.urihttps://doi.org/10.1007/s11255-019-02102-8-
dc.description.abstractPurpose: Acute pyelonephritis is associated with considerable morbidity and potential for renal scarring. Pentraxin3 (PTX3) is a recently discovered mediator of inflammation. The objective of this study was to investigate the changes in serum and urine PTX3 levels in children who had a history of pyelonephritis and were diagnosed with renal parenchymal scar (RPS) and/or vesicoureteral reflux (VUR). Methods: The study included 88 children (31 males, 57 females) aged between 3 months and 18 years. The children included in the study were divided into four groups: VUR with RPS (Group 1), RPS without VUR (Group 2), VUR without RPS (Group 3), and healthy children without a history of hydronephrosis or UTI history (Group 4). After the initial evaluation, the participants were further divided into two more groups and re-evaluated: Children with RPS (Group 1 + 2), children without RPS (Group 3 + 4), children with VUR (Group 1 + 3), and children without VUR (Group 2 + 4). Results: We found that urine pentraxin 3 (uPTX3) and uPTX3/Creatinine levels were significantly higher in the groups with renal scar with or without VUR than the ones without RPS [mean uPTX3, 3.5 pg/ml (min–max 0.0022–12.3668) vs. 2.2 pg/ml (min–max 0.0022–18.5868) and uPTX3/creatinine, 10.5 pg/mg (min–max 0.0035–51.1) vs. 5.8 pg/mg (min–max 0.0004–78.7), p < 0.01]. uPTX3 levels were not different among the groups with and without VUR. In addition, serum PTX3 levels were not different among the groups. Conclusions: We showed that urinary PTX3 increased only in patients with scarred kidneys. These results might be helpful to predict RPS due to past pyelonephritis. © 2019, Springer Nature B.V.en_US
dc.language.isoenen_US
dc.publisherSpringer Netherlandsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectPentraxin 3en_US
dc.subjectRenal scaren_US
dc.subjectVesicoureteral refluxen_US
dc.subjectcreatinineen_US
dc.subjectpentraxin 3en_US
dc.subjectbiological markeren_US
dc.subjectC reactive proteinen_US
dc.subjectserum amyloid Pen_US
dc.subjectacute pyelonephritisen_US
dc.subjectadolescenten_US
dc.subjectadulten_US
dc.subjectArticleen_US
dc.subjectchilden_US
dc.subjectclinical evaluationen_US
dc.subjectcorrelational studyen_US
dc.subjectdisease associationen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectinfanten_US
dc.subjectkidney parenchymaen_US
dc.subjectkidney scaren_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmedical historyen_US
dc.subjectprotein urine levelen_US
dc.subjecturinary excretionen_US
dc.subjectvesicoureteral refluxen_US
dc.subjectacute diseaseen_US
dc.subjectblooden_US
dc.subjectcase control studyen_US
dc.subjectcomplicationen_US
dc.subjectmetabolismen_US
dc.subjectpreschool childen_US
dc.subjectpyelonephritisen_US
dc.subjectscaren_US
dc.subjecturineen_US
dc.subjectAcute Diseaseen_US
dc.subjectAdolescenten_US
dc.subjectBiomarkersen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectCase-Control Studiesen_US
dc.subjectChilden_US
dc.subjectChild, Preschoolen_US
dc.subjectCicatrixen_US
dc.subjectCreatinineen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectInfanten_US
dc.subjectMaleen_US
dc.subjectPyelonephritisen_US
dc.subjectSerum Amyloid P-Componenten_US
dc.subjectVesico-Ureteral Refluxen_US
dc.titleUrinary excretion of pentraxin-3 correlates with the presence of renal scar following acute pyelonephritis in childrenen_US
dc.typeArticleen_US
dc.identifier.volume51en_US
dc.identifier.issue4en_US
dc.identifier.startpage571
dc.identifier.startpage571en_US
dc.identifier.endpage577en_US
dc.authorid0000-0001-9415-1640-
dc.identifier.doi10.1007/s11255-019-02102-8-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid30796728en_US
dc.identifier.scopus2-s2.0-85061988993en_US
dc.identifier.wosWOS:000464869600002en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.languageiso639-1en-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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