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https://hdl.handle.net/11499/30244
Title: | The determination of the potential anticancer effects of Coriandrum sativum in PC-3 and LNCaP prostate cancer cell lines | Authors: | Elmas, Levent Seçme, Mücahit Mammadov, Ramazan Fahrioglu, U. Dodurga, Yavuz |
Keywords: | coriander herbal medicine LNCaP PC-3 prostate cancer apoptotic protease activating factor 1 caspase 10 caspase 9 Coriandrum sativum extract death receptor 4 death receptor 5 phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein bcl 2 protein Bid protein kinase B protein Noxa protein p53 PUMA protein tumor necrosis factor receptor associated death domain protein antineoplastic activity Article cell invasion cell migration cell viability colony formation controlled study cytotoxicity gene expression human human cell IC50 in vitro study LNCaP cell line PC-3 [Human prostate carcinoma] cell line priority journal prostate cancer cell line |
Publisher: | Wiley-Liss Inc. | Abstract: | Coriander (Coriandrum sativum L.) is such an herb from the Apiaceae family, used both for its medicinal and nutritional properties for many centuries. In this study, the effects of C. sativum extract on gene expression, viability, colony formation, migration, and invasion of PC-3 and LNCaP prostate cancer cell lines have been investigated. The half maximal inhibitory concentration (IC 50 ) dose in PC-3 and LNCaP cells was detected to be 2 and 5 mg/mL at the 24th hour, respectively. C. sativum extracts have been observed to cause a significant decrease in the expression of Akt and Bcl-2 in the PC-3 cells and just Akt in LNCaP cells while increasing in the expression of p53, caspase-9, caspase-10, PTEN, DR5, TRADD, PUMA, and NOXA. DR4 expression was increased in LNCaP cell line but not PC-3, and APAF and BID had increased expression in PC-3 but not the LNCaP cells. Our observations have shown that C. sativum extract decreased colony formation while inhibiting cell invasion and migration. Cell migration was hindered in PC-3 but not the LNCaP cells. In conclusion, this data present a valuable addition to the very limited data available out there on the potential use of C. sativum in prostate cancer treatment. © 2018 Wiley Periodicals, Inc. | URI: | https://hdl.handle.net/11499/30244 https://doi.org/10.1002/jcb.27625 |
ISSN: | 0730-2312 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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