Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/30258
Title: Interaction of a new copper(II) complex by bovine serum albumin and dipeptidyl peptidase-IV
Authors: İnci, D.
Köseler, Aylin
Zeytünlüoğlu, Ali
Aydın, R.
Zorlu, Y.
Keywords: Bovine serum albumine (BSA)
Cu(II) complexes
dipeptidyl peptidase-IV (DPP-IV)
Phenylalanine
pyrazino[2,3-f] [1,10]phenanthroline
Amino acids
Body fluids
Chromophores
Fluorescence spectroscopy
Fourier transform infrared spectroscopy
Mammals
Single crystals
Surface plasmon resonance
Bovine serum albumine
Cu complexes
Dipeptidyl peptidase iv
Phenanthrolines
Copper compounds
Publisher: Elsevier B.V.
Abstract: Dipeptidyl peptidase-IV (DPP-IV) is one of the mammalian serine proteases participated in the pathogenesis of diseases and DPP-IV inhibitors are now widely used as antidiabetic drugs. A new water soluble ternary copper (II) complex,-[Cu(py-phen) (phe) (H2O)]NO3·H2O-(py-phen:pyrazino[2,3f][1,10]phenanthroline, phe:phenylalanine), has been synthesized and characterized by CHN analysis, ESI-MS, FTIR and single-crystal X-ray diffraction techniques. Fluorescence spectroscopy was researched to study the interaction between the complex and bovine serum albumin (BSA) and dipeptidyl peptidase-IV (DPP-IV). Chromophore of BSA and DPP-IV enzyme is changed upon addition of the complex. Additionally, the complex was shown to have promising inhibitory activities against DPP-IV with lower IC50 value. This study may provide new insights into the development of effective agents against diabetes. © 2018 Elsevier B.V.
URI: https://hdl.handle.net/11499/30258
https://doi.org/10.1016/j.molstruc.2018.09.086
ISSN: 0022-2860
Appears in Collections:Denizli Teknik Bilimler Meslek Yüksekokulu Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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