Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/30271
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dc.contributor.authorYola, M.L.-
dc.contributor.authorAtar, Necip-
dc.date.accessioned2020-06-08T12:12:08Z
dc.date.available2020-06-08T12:12:08Z
dc.date.issued2019-
dc.identifier.issn0956-5663-
dc.identifier.urihttps://hdl.handle.net/11499/30271-
dc.identifier.urihttps://doi.org/10.1016/j.bios.2018.11.016-
dc.description.abstractThe cardiac Troponin-I (cTnI) is one of the subunits of cardiac troponin complexes and a pivotal biochemical marker of acute myocardial infarction (AMI). Due to its myocardial specificity, cTnI is widely used for the diagnosis of AMI diseases. In this study, a novel imprinted biosensor approach based on boron nitride quantum dots (BNQDs) was presented for cTnI detection in plasma samples. Various characterization methods such as scanning electron microscope (SEM), transmission electron microscope (TEM), x-ray diffraction (XRD), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used for all characterizations of nanomaterials. After the characterization analysis, cTnI imprinted electrode was developed in the presence of 100.0 mM pyrrole containing 25.0 mM cTnI. After that, the analytical studies of cTnI in plasma samples were performed by using cTnI imprinted biosensor. The results of the study have revealed that 0.01–5.00 ng mL -1 and 0.0005 ng mL -1 were found as the linearity range and the detection limit (LOD). Moreover, the selectivity of cTnI imprinted glassy carbon electrode (GCE) was investigated for plasma sample analysis in the presence of other nonspecific and specific proteins including cardiac myoglobin (MYG), bovine serum albumin (BSA) and cardiac troponin T (cTnT), respectively. Furthermore, the prepared biosensor was examined in terms of stability, repeatability, reproducibility and reusability. Finally, the imprinted biosensor was applied to the plasma samples having high recovery. © 2018 Elsevier B.V.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBoron nitride quantum dotsen_US
dc.subjectCardiac Troponin-Ien_US
dc.subjectMolecular imprinted biosensoren_US
dc.subjectPlasmaen_US
dc.subjectBiochemistryen_US
dc.subjectBiosensorsen_US
dc.subjectBody fluidsen_US
dc.subjectBoron nitrideen_US
dc.subjectCyclic voltammetryen_US
dc.subjectDiagnosisen_US
dc.subjectDrug productsen_US
dc.subjectElectrochemical impedance spectroscopyen_US
dc.subjectGlass membrane electrodesen_US
dc.subjectHearten_US
dc.subjectIII-V semiconductorsen_US
dc.subjectMammalsen_US
dc.subjectNanocrystalsen_US
dc.subjectNitridesen_US
dc.subjectPlasmasen_US
dc.subjectReusabilityen_US
dc.subjectScanning electron microscopyen_US
dc.subjectTransmission electron microscopyen_US
dc.subjectAcute myocardial infarctionen_US
dc.subjectBiochemical markersen_US
dc.subjectBovine serum albuminsen_US
dc.subjectCardiac troponin Ien_US
dc.subjectCharacterization methodsen_US
dc.subjectGlassy carbon electrodesen_US
dc.subjectMolecular imprinted biosensorsen_US
dc.subjectMolecularly Imprinted Polymeren_US
dc.subjectSemiconductor quantum dotsen_US
dc.subjectboron nitride quantum doten_US
dc.subjectbovine serum albuminen_US
dc.subjectmolecularly imprinted polymeren_US
dc.subjectmyoglobinen_US
dc.subjectpyrroleen_US
dc.subjectquantum doten_US
dc.subjecttroponin Ien_US
dc.subjecttroponin Ten_US
dc.subjectunclassified drugen_US
dc.subjectboron derivativeen_US
dc.subjectboron nitrideen_US
dc.subjectcarbonen_US
dc.subjectpolymeren_US
dc.subjectArticleen_US
dc.subjectcontrolled studyen_US
dc.subjectglassy carbon electrodeen_US
dc.subjecthumanen_US
dc.subjectimpedance spectroscopyen_US
dc.subjectlimit of detectionen_US
dc.subjectmeasurement repeatabilityen_US
dc.subjectprotein blood levelen_US
dc.subjectreproducibilityen_US
dc.subjectscanning electron microscopyen_US
dc.subjecttransmission electron microscopyen_US
dc.subjectX ray diffractionen_US
dc.subjectchemistryen_US
dc.subjectgenetic proceduresen_US
dc.subjectisolation and purificationen_US
dc.subjectmolecular imprintingen_US
dc.subjectBiosensing Techniquesen_US
dc.subjectBoron Compoundsen_US
dc.subjectCarbonen_US
dc.subjectDielectric Spectroscopyen_US
dc.subjectHumansen_US
dc.subjectLimit of Detectionen_US
dc.subjectMolecular Imprintingen_US
dc.subjectMyoglobinen_US
dc.subjectPolymersen_US
dc.subjectQuantum Dotsen_US
dc.subjectSerum Albumin, Bovineen_US
dc.subjectTroponin Ien_US
dc.subjectTroponin Ten_US
dc.titleDevelopment of cardiac troponin-I biosensor based on boron nitride quantum dots including molecularly imprinted polymeren_US
dc.typeArticleen_US
dc.identifier.volume126en_US
dc.identifier.startpage418
dc.identifier.startpage418en_US
dc.identifier.endpage424en_US
dc.identifier.doi10.1016/j.bios.2018.11.016-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid30471567en_US
dc.identifier.scopus2-s2.0-85056775594en_US
dc.identifier.wosWOS:000457659500053en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale University-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
crisitem.author.dept10.03. Chemical Engineering-
Appears in Collections:Mühendislik Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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