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https://hdl.handle.net/11499/30272
Title: | Ameliorative effect of certolizumab on experimentally induced acute necrotic pancreatitis in rats | Authors: | Kosekli, M.A. Herek, Özkan Ozmen, Ö. Sahinduran, S. |
Keywords: | Certolizumab Pegol Pancreatitis, acute necrotizing Rats 3,4 methylenedioxyamphetamine amylase certolizumab pegol lactate dehydrogenase monoclonal antibody taurocholic acid triacylglycerol lipase tumor necrosis factor immunosuppressive agent acute hemorrhagic pancreatitis amylase blood level animal experiment Article controlled study enzyme activity enzyme blood level fat necrosis histopathology immunohistochemistry lactate dehydrogenase blood level male nonhuman pancreatic duct randomized controlled trial rat scoring system triacylglycerol lipase blood level animal chemically induced disease model pathology Wistar rat Animals Disease Models, Animal Immunosuppressive Agents Male Pancreatitis, Acute Necrotizing Rats, Wistar Taurocholic Acid |
Publisher: | Associacao Medica Brasileira | Abstract: | OBJECTIVE: The effects of Certolizumab, a pegylated monoclonal antibody to tumor necrosis factor ?, on experimentally induced acute pancreatitis (AP) were examined. METHODS: Thirty-six Wistar Albino male rats were randomly divided into four groups. Group I was the control group and no medication administered to this group. Group II was the Certolizumab group, and 100 ml/kg serum physiologic administered into the biliopancreatic duct and a single dose of 10 µg Certolizumab was simultaneously administered intraperitoneally. Acute pancreatitis was induced with a retrograde injection of 3% Na taurocholate into the common biliopancreatic duct in the study (Group III) and treatment (Groups IV) groups. Rats were sacrificed 72 hours later. Serum amylase, lipase, lactate dehydrogenase activities, along with pancreatic histo-pathology, were examined. RESULTS: Certolizumab treatment significantly decreased serum amylase, lipase, and LDH levels; histopathologically edema, hemorrhage, parenchymal necrosis, fat necrosis, and infiltration scores; immunohistochemically MDA, MPO, TNF-? and Caspase-3 activity. CONCLUSION: The results support the idea that certolizumab might be beneficial for the severity of AP. © 2019 Associacao Medica Brasileira. All rights reserved. | URI: | https://hdl.handle.net/11499/30272 https://doi.org/10.1590/1806-9282.65.2.204 |
ISSN: | 0104-4230 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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