Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/30272
Title: Ameliorative effect of certolizumab on experimentally induced acute necrotic pancreatitis in rats
Authors: Kosekli, M.A.
Herek, Özkan
Ozmen, Ö.
Sahinduran, S.
Keywords: Certolizumab Pegol
Pancreatitis, acute necrotizing
Rats
3,4 methylenedioxyamphetamine
amylase
certolizumab pegol
lactate dehydrogenase
monoclonal antibody
taurocholic acid
triacylglycerol lipase
tumor necrosis factor
immunosuppressive agent
acute hemorrhagic pancreatitis
amylase blood level
animal experiment
Article
controlled study
enzyme activity
enzyme blood level
fat necrosis
histopathology
immunohistochemistry
lactate dehydrogenase blood level
male
nonhuman
pancreatic duct
randomized controlled trial
rat
scoring system
triacylglycerol lipase blood level
animal
chemically induced
disease model
pathology
Wistar rat
Animals
Disease Models, Animal
Immunosuppressive Agents
Male
Pancreatitis, Acute Necrotizing
Rats, Wistar
Taurocholic Acid
Publisher: Associacao Medica Brasileira
Abstract: OBJECTIVE: The effects of Certolizumab, a pegylated monoclonal antibody to tumor necrosis factor ?, on experimentally induced acute pancreatitis (AP) were examined. METHODS: Thirty-six Wistar Albino male rats were randomly divided into four groups. Group I was the control group and no medication administered to this group. Group II was the Certolizumab group, and 100 ml/kg serum physiologic administered into the biliopancreatic duct and a single dose of 10 µg Certolizumab was simultaneously administered intraperitoneally. Acute pancreatitis was induced with a retrograde injection of 3% Na taurocholate into the common biliopancreatic duct in the study (Group III) and treatment (Groups IV) groups. Rats were sacrificed 72 hours later. Serum amylase, lipase, lactate dehydrogenase activities, along with pancreatic histo-pathology, were examined. RESULTS: Certolizumab treatment significantly decreased serum amylase, lipase, and LDH levels; histopathologically edema, hemorrhage, parenchymal necrosis, fat necrosis, and infiltration scores; immunohistochemically MDA, MPO, TNF-? and Caspase-3 activity. CONCLUSION: The results support the idea that certolizumab might be beneficial for the severity of AP. © 2019 Associacao Medica Brasileira. All rights reserved.
URI: https://hdl.handle.net/11499/30272
https://doi.org/10.1590/1806-9282.65.2.204
ISSN: 0104-4230
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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