Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/30354
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dc.contributor.authorKaleli, İlknur-
dc.contributor.authorAksoy, Levent-
dc.contributor.authorDemir, Melek-
dc.contributor.authorMete, Ergun-
dc.contributor.authorÖner, Sedef Zeliha-
dc.contributor.authorBir, Ferda-
dc.contributor.authorKaleli, Babür-
dc.date.accessioned2020-06-08T12:12:42Z-
dc.date.available2020-06-08T12:12:42Z-
dc.date.issued2019-
dc.identifier.issn0374-9096-
dc.identifier.urihttps://hdl.handle.net/11499/30354-
dc.identifier.urihttps://doi.org/10.5578/mb.67765-
dc.description.abstractHuman papillomavirus (HPV) infection is the most significant risk factor of the development of cervical cancer. The distribution of HPV prevalence and genotype varies widely between regions. In this study, it was aimed to investigate the prevalence and genotype distribution of HPV, retrospectively. One thousand one hundred and seventy patients who applied to the department of obstetrics and gynecology were included in this study. Samples were collected from patients for cervical HPV DNA and Pap smear. The Pap samples taken for Pap smear were fixed with alcohol and analyzed according to the modified Bethesda system. HPV identification and typing were performed using the "Linear Array HPV Genotyping Test (Roche Molecular System, USA)". Patients were divided into 5 groups due to their age. Total HPV ratio was most frequently found among the patients who were between 17-30 years old, while HR-HPV was most frequently found between 51-60 years. Nine hundred seventy-eight of 1170 (83.6%) patients had normal cytologic findings whereas 192 (16.4%) had abnormal cytologic findings. HPV was detected in 37.2% of the total patients. high-risk HPV (HR-HPV) rate was 21.2%, probable high risk (PR-HPV) rate was 6.4% and low risk HPV (LR-HPV) rate was 9.5%. When the relationship between cytologic findings and HPV was examined, normal cytology/HPV negative 67.8%; abnormal cytology/HPV negative 37.5%, normal cytology/HPV positive 32.2%, abnormal cytology/HPV positive 62.5% were detected. The highest prevalence of HPV was 8.9% with HPV 16, followed by 6, 53 and 52/53/35/58. A total of 354 patients were biopsied, 177 of whom were normal, 111 of whom were cervical intraepithelial neoplasia (CIN) 1, 66 of whom were CIN 2 and over. In the group with normal pathological findings, HR-HPV ratio was found as 15.8%, while in CIN 1 44.1% in CIN 2-3 63.6%. Sensitivity, specificity, positive predictive value, and negative predictive value of screening tests were examined in CIN 2 and more lesions. Sensitivity and specificity for HR-HPV were 63.6% and 73.3%, respectively, the same rates were 81.8% and 58.7% for HPV. The highest sensitivity was found in combination of HRHPV and Pap smear, the highest specificity in HPV. In conclusion, the HPV prevalence and genotype distribution in our study are similar to those reported in the world, but higher than previous studies in our country. These results may be due to our methodology and hospital based nature of our study group. We conclude that only smear or HR-HPV testing are not sufficient as a single pronged screening test, and that the participation of other genotypes of HPV in screening increases the sensitivity. © 2019 Ankara Microbiology Society. All rights reserved.en_US
dc.language.isotren_US
dc.publisherAnkara Microbiology Societyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCervical cytologyen_US
dc.subjectGenotypeen_US
dc.subjectHuman papillomavirusen_US
dc.subjectPap smearen_US
dc.subjectvirus DNAen_US
dc.subjectadolescenten_US
dc.subjectadulten_US
dc.subjectfemaleen_US
dc.subjectgeneticsen_US
dc.subjectgenotypeen_US
dc.subjectgynecologyen_US
dc.subjecthumanen_US
dc.subjectPapanicolaou testen_US
dc.subjectPapillomaviridaeen_US
dc.subjectpapillomavirus infectionen_US
dc.subjectprevalenceen_US
dc.subjectretrospective studyen_US
dc.subjectvirologyen_US
dc.subjectyoung adulten_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectDNA, Viralen_US
dc.subjectFemaleen_US
dc.subjectGynecologyen_US
dc.subjectHumansen_US
dc.subjectPapanicolaou Testen_US
dc.subjectPapillomavirus Infectionsen_US
dc.subjectPrevalenceen_US
dc.subjectRetrospective Studiesen_US
dc.subjectYoung Adulten_US
dc.titlePrevalence and genotype distribution of human papillomavirus in patients attending to gynecology polyclinicsen_US
dc.title.alternativeJinekoloji Polikliniğine Başvuran Hastalarda İnsan Papillomavirüs Prevalansı ve Genotip Dağılımıen_US
dc.typeArticleen_US
dc.identifier.volume53en_US
dc.identifier.issue2en_US
dc.identifier.startpage170-
dc.identifier.startpage170en_US
dc.identifier.endpage178en_US
dc.identifier.doi10.5578/mb.67765-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid31130121en_US
dc.identifier.scopus2-s2.0-85066950890en_US
dc.identifier.trdizinid371555en_US
dc.identifier.wosWOS:000465377600005en_US
dc.identifier.scopusqualityQ3-
dc.ownerPamukkale University-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1tr-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.01. Surgical Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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