Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/30385
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dc.contributor.authorSever, Nurettin İlter-
dc.contributor.authorCengiz Şahin, Sevilay-
dc.date.accessioned2020-06-08T12:12:54Z
dc.date.available2020-06-08T12:12:54Z
dc.date.issued2019-
dc.identifier.issn1479-6694-
dc.identifier.urihttps://hdl.handle.net/11499/30385-
dc.identifier.urihttps://doi.org/10.2217/fon-2018-0332-
dc.description.abstractS6K2, the newer member of S6 Kinase family, is a crucial modulator of Akt/mTOR signaling pathway and is a member of AGC kinase family that regulates cellular growth and survival. S6K1 and S6K2 share high sequence similarity; therefore, S6K2 had been underestimated. However, recent studies displayed distinct functions of S6K2. Activated by both Akt/mTOR and Ras/Raf/Mek/Erk signaling pathways, S6K2 regulates cancer cell survival via different routes. Complexation with antiapoptotic proteins BRAF and PKC? avoids non-small-cell lung cancer cells from apoptosis upon FGF-2 stimulation. Indirect upregulation of the translation of antiapoptotic proteins Bcl-XL and XIAP in HEK293T cells and interference with TNF-induced apoptosis in MCF-7 cells are other routes of cancer cell survival. The aforementioned studies on S6K2 necessitate the development of therapies targeting only on S6K2. Studies targeting S6K2 may help to build important roads for cancer therapy. © 2018 Future Medicine Ltd.en_US
dc.language.isoenen_US
dc.publisherFuture Medicine Ltd.en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcancer cell survivalen_US
dc.subjectcancer therapyen_US
dc.subjectS6 kinase 2en_US
dc.subjectB Raf kinaseen_US
dc.subjectfibroblast growth factor 2en_US
dc.subjectinitiation factor 4E binding protein 1en_US
dc.subjectmammalian target of rapamycinen_US
dc.subjectmitogen activated protein kinaseen_US
dc.subjectpf 4708671en_US
dc.subjectprotein bcl xlen_US
dc.subjectprotein kinase Ben_US
dc.subjectprotein kinase inhibitoren_US
dc.subjectRaf proteinen_US
dc.subjectRas proteinen_US
dc.subjectS6 kinaseen_US
dc.subjectunclassified drugen_US
dc.subjectX linked inhibitor of apoptosisen_US
dc.subjectribosomal protein S6 kinase, 70kD, polypeptide 2en_US
dc.subjectAkt/mTOR signalingen_US
dc.subjectapoptosisen_US
dc.subjectbreast canceren_US
dc.subjectcancer cellen_US
dc.subjectcancer prognosisen_US
dc.subjectcell growthen_US
dc.subjectcell proliferationen_US
dc.subjectcell survivalen_US
dc.subjectcomplex formationen_US
dc.subjectcorrelation analysisen_US
dc.subjectdrug targetingen_US
dc.subjectenzyme activationen_US
dc.subjectenzyme structureen_US
dc.subjectHEK293 cell lineen_US
dc.subjecthumanen_US
dc.subjectmalignant neoplasmen_US
dc.subjectMCF-7 cell lineen_US
dc.subjectnon small cell lung canceren_US
dc.subjectpriority journalen_US
dc.subjectprotein expressionen_US
dc.subjectprotein familyen_US
dc.subjectprotein functionen_US
dc.subjectprotein localizationen_US
dc.subjectReviewen_US
dc.subjectsequence homologyen_US
dc.subjectsignal transductionen_US
dc.subjectupregulationen_US
dc.subjectchemistryen_US
dc.subjectenzymologyen_US
dc.subjectmetabolismen_US
dc.subjectmolecularly targeted therapyen_US
dc.subjectneoplasmen_US
dc.subjectpathologyen_US
dc.subjectproceduresen_US
dc.subjectCell Proliferationen_US
dc.subjectHumansen_US
dc.subjectMolecular Targeted Therapyen_US
dc.subjectNeoplasmsen_US
dc.subjectRibosomal Protein S6 Kinases, 70-kDaen_US
dc.titleS6K2 promises an important therapeutic potential for canceren_US
dc.typeReviewen_US
dc.identifier.volume15en_US
dc.identifier.issue1en_US
dc.identifier.startpage3306
dc.identifier.startpage3306en_US
dc.identifier.endpage3316en_US
dc.authorid0000-0002-9320-4146-
dc.authorid0000-0003-3361-4319-
dc.identifier.doi10.2217/fon-2018-0332-
dc.relation.publicationcategoryDiğeren_US
dc.identifier.pmid30730779en_US
dc.identifier.scopus2-s2.0-85058448121en_US
dc.identifier.wosWOS:000453874200010en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairetypeReview-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.dept17.05. Molecular Biology and Genetics-
crisitem.author.dept17.05. Molecular Biology and Genetics-
Appears in Collections:Fen-Edebiyat Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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