Poly (Lactic Acid) Nano-fibers as Drug-delivery Systems: Opportunities and challenges

Abstract

Numerous Scientists have discovered the procedure of nano-technology, explicitly nano-fibers, as drug-delivery systems for trans-dermal uses. Nano-fibers can be used to deliver drugs and are capable of controlled-release for a continued period of time. Poly (Lactic Acid) (PLA) is the lastly interesting employed synthetic polymer in bio-medical usage owing to its well categorized biodegradable properties. PLA (?[CH(CH3)COO]n–)is linear biodegradable aliphatic polyester which can be derived from 100% re-newable bio-resources like rice and wheat through fermentation and polymerization. PLA has been accepted by FDA to be applied in bio-materials, for instance sutures, bone plates, abdominal mesh, and drug-delivery systems. PLA holds stereo-isomers, for instance Poly (L-Lactide) (PLLA), Poly(D-Lactide) (PDLA), and Poly(DL-Lactide) (PDLLA). PLGA is a co-polymer of PLA and Poly (Glycolic Acid) (PGA) that are most usually used biodegradable synthetic polymers for bio-medical uses for instance scaffolds and drug-delivery systems. The objective of this review paper is to highpoint the possibility of PLA nano-fibres as drug-delivery substances and to give full information about the new progresses about the PLA, PLLA and PLGA nano-fibers fabrication as novel drug-delivery systems. © 2019 Tehran University of Medical Sciences. All rights reserved.