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https://hdl.handle.net/11499/30484
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cavdar, Z. | - |
dc.contributor.author | Ural, C. | - |
dc.contributor.author | Kocak, A. | - |
dc.contributor.author | Arslan, Şevki. | - |
dc.contributor.author | Ersan, S. | - |
dc.contributor.author | Ozbal, S. | - |
dc.contributor.author | Tatli, M. | - |
dc.date.accessioned | 2020-06-08T12:13:44Z | - |
dc.date.available | 2020-06-08T12:13:44Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0250-4685 | - |
dc.identifier.uri | https://hdl.handle.net/11499/30484 | - |
dc.identifier.uri | https://doi.org/10.1515/tjb-2018-0155 | - |
dc.description.abstract | Objective: This study aimed to investigate the renoprotective effects of paricalcitol, a synhetic vitamin D analog, through its possible roles on p38 MAPK and PI3K/Akt signaling pathways to prevent oxidative stress, inflammation and apoptosis during renal I/R. Materials and methods: Total 20 kidney tissues of sham (n = 6), subjected to renal I/R bilaterally for 45 min ischemia followed by 24 h reperfusion (n = 7) and paricalcitol (0.3 µg/kg, ip) pretreated Wistar albino rats (n = 7) were used in this study. Interstitial inflammation and active caspase-3 expression were evaluated histologically. TNF-?, IL-1ß, kidney injury molecule-1 (KIM-1), MDA and SOD activity in kidneys were analysed biochemically. Furthermore, activation of p38 MAPK, PI3K/Akt signaling pathways and NF?B p65 were evaluated by western blot. Results: Paricalcitol pretreatment significantly reduced interstitial inflammation during renal I/R, which was consistent with decreased tumor TNF-?, IL-1ß, active caspase-3 and KIM-1 expression. Paricalcitol also reduced MDA level and attenuated the reduction of SOD activity in the kidney during I/R. Moreover, paricalcitol could suppress the p38 MAPK and NF?B p65, and also activate PI3K/Akt signaling pathway during renal I/R. Conclusion: All these findings indicate that paricalcitol may be an effective practical strategy to prevent renal I/R injury. © 2019 De Gruyter. All rights reserved. | en_US |
dc.language.iso | en | en_US |
dc.publisher | De Gruyter | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Ischemia | en_US |
dc.subject | Kidney | en_US |
dc.subject | P38 MAPK | en_US |
dc.subject | Paricalcitol | en_US |
dc.subject | PI3K/Akt | en_US |
dc.subject | caspase 3 | en_US |
dc.subject | interleukin 1beta | en_US |
dc.subject | kidney injury molecule 1 | en_US |
dc.subject | malonaldehyde | en_US |
dc.subject | mitogen activated protein kinase p38 | en_US |
dc.subject | paricalcitol | en_US |
dc.subject | superoxide dismutase | en_US |
dc.subject | transcription factor RelA | en_US |
dc.subject | tumor necrosis factor | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal model | en_US |
dc.subject | animal tissue | en_US |
dc.subject | apoptosis | en_US |
dc.subject | biochemical analysis | en_US |
dc.subject | Conference Paper | en_US |
dc.subject | drug mechanism | en_US |
dc.subject | enzyme activation | en_US |
dc.subject | enzyme inhibition | en_US |
dc.subject | histology | en_US |
dc.subject | inflammation | en_US |
dc.subject | male | en_US |
dc.subject | nonhuman | en_US |
dc.subject | oxidative stress | en_US |
dc.subject | Pi3K/Akt signaling | en_US |
dc.subject | protein expression | en_US |
dc.subject | rat | en_US |
dc.subject | renal ischemia reperfusion injury | en_US |
dc.subject | renal protection | en_US |
dc.subject | signal transduction | en_US |
dc.subject | Western blotting | en_US |
dc.subject | Wistar rat | en_US |
dc.title | Paricalcitol pretreatment attenuates renal ischemia/reperfusion injury by inhibiting p38 MAPK and activating PI3K/Akt signaling pathways | en_US |
dc.type | Conference Object | en_US |
dc.identifier.volume | 44 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 452 | - |
dc.identifier.startpage | 452 | en_US |
dc.identifier.endpage | 461 | en_US |
dc.identifier.doi | 10.1515/tjb-2018-0155 | - |
dc.relation.publicationcategory | Konferans Öğesi - Ulusal - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopus | 2-s2.0-85073574934 | en_US |
dc.identifier.trdizinid | 340491 | en_US |
dc.identifier.wos | WOS:000489303900005 | en_US |
dc.identifier.scopusquality | Q4 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.openairetype | Conference Object | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 07.01. Basic Islamic Sciences | - |
crisitem.author.dept | 17.02. Biology | - |
Appears in Collections: | Fen-Edebiyat Fakültesi Koleksiyonu Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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document (2).pdf | 1.12 MB | Adobe PDF | View/Open |
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