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https://hdl.handle.net/11499/30532
Title: | The prevalence of mixed genotype infections in Turkish patients with hepatitis C: A multicentered assessment | Authors: | Kulah, C. Altindis, M. Akyar, I. Gokahmetoglu, S. Sayiner, A. Kaleli, İlknur. Fidan, I. |
Keywords: | Genotypes HCV Mixed genotypes Multicenter Turkey adolescent adult Article controlled study female gene sequence genotype geographic distribution hepatitis C Hepatitis C virus genotype 2 Hepatitis C virus genotype 3 Hepatitis C virus genotype 4 Hepatitis C virus genotype 6 Hepatitis C virus subtype 1a Hepatitis C virus subtype 1b Hepatitis C virus subtype 2a Hepatitis C virus subtype 2b Hepatitis C virus subtype 2c Hepatitis C virus subtype 3a Hepatitis C virus subtype 4a Hepatitis C virus subtype 4c Hepatitis C virus subtype 4d human hybridization infant major clinical study male middle aged mixed infection newborn prevalence pyrosequencing real time polymerase chain reaction restriction fragment length polymorphism reverse hybridization Turkey (republic) Turkish citizen aged clinical trial genetics geography Hepacivirus liver cirrhosis liver tumor multicenter study turkey (bird) virology young adult virus RNA Adolescent Adult Aged Coinfection Female Genotype Geography Hepatitis C Humans Liver Cirrhosis Liver Neoplasms Male Middle Aged Polymorphism, Restriction Fragment Length Prevalence RNA, Viral Young Adult |
Publisher: | Verlag Klinisches Labor GmbH | Abstract: | Background: HCV virus infections are one of the major health problems in the world that can cause cirrhosis and liver cancer at a higher rate than other hepatitis data. The aim of this study was to determine the prevalence of mixed infections with different HCV genotypes in Turkey and also to evaluate the current HCV genotype and subtype distributions by a multicentered assessment. Methods: The HCV genotype data of 17,578 hepatitis C patients collected from 23 centers from different geographic regions covering all Turkey were collected. The data included information about the HCV genotypes in the last 10 years (between 2007 and 2016), demographic properties of the patients and the methods/systems used to determine the genotypes. Results: Two hundred twenty-eight of the patients (1.3%) had mixed genotype. The most common mixed genotype combination was 1b + 4 (0.83%) followed by 1a + 1b (0.26%). Genotype distribution varies according to geographical regions. However, genotype 1 (82.92%) was the most common genotype in all regions and all years. This was followed by genotype 3 (7.07%) and genotype 4 (5.43%). A variety of methods were used by the centers including sequencing, pyrosequencing, real-time PCR, in-house RFLP, reverse hybridization (LIPA), and hybridization. Conclusions: Infection with mixed HCV genotypes in Turkey is uncommon. Genotype distribution varies according to geographic regions; the most common genotype 1 is encountered all over the country, while genotypes 3 and 4 are only in some of the centers. Since there is limited information about mixed HCV infection, further investigations are needed to determine the clinical importance of mixed HCV infection. © 2019 Verlag Klinisches Labor GmbH. All rights reserved. | URI: | https://hdl.handle.net/11499/30532 https://doi.org/10.7754/Clin.Lab.2018.180824 |
ISSN: | 1433-6510 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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