Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/32537
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dc.contributor.authorYıldırım, Ayşegül B.-
dc.contributor.authorÖzdamar, Saim-
dc.contributor.authorYalçın, Betül-
dc.contributor.authorKarabulut, Derya-
dc.date.accessioned2020-06-08T13:48:40Z
dc.date.available2020-06-08T13:48:40Z
dc.date.issued2019-
dc.identifier.issn1136-4890-
dc.identifier.urihttps://hdl.handle.net/11499/32537-
dc.description.abstractAn absence of the thyroid hormone during the critical period of brain development causes delayed maturation of glial cells and neurons and decreases the number of hippocampal cells. This study aims to examine the impact of maternal subclinical hypothyroidism (SCH) on pup hippocampus during the prepubertal and pubertal periods by means of assessing the histopathological changes in astrocytes and neurons.en_US
dc.description.abstractTwelve Wistar albino pregnant rats were divided into two groups, Group H and Group C. Group C was designated as the control group and nothing was added to their drinking water. SCH was induced in Group H by administering 6-propyl-2-thiouracil (PTU) at a final concentration of 0.01% in the drinking water of pregnant rats for 21 days. Male pups for each group were divided evenly and evaluated on either day 15 (prepubertal) or 60 (pubertal) (7 pups in each group). At the end of the experimental period, the rats were sacrificed for analysis of brain tissue.en_US
dc.description.abstractImmunoreactivity intensities of MAP-2 and GFAP were evaluated in hippocampus tissue. Thyroid function was determined using ELISA. The structure of hippocampus was evaluated by hematoxylin-eosin staining. Finally, the TUNEL method was utilized to show apoptosis of hippocampus tissue. The results were analyzed statistically.en_US
dc.description.abstractThe findings show that maternal SCH causes disruption in hippocampal cytoskeleton and dendritic organization, especially during the pubertal period, as well as a decrease in MAP-2 expression. We observed structural deformation in astrocytes, reduced astrocyte survival and GFAP expression. Finally, we found that the number of neuronal apoptotic cells tended to increase in the pubertal period.en_US
dc.description.abstractC1 [Yildirim, Aysegul B.] Kahramanmaras Sutcu Imam Univ, Dept Histol & Embryol, Kahramanmaras, Turkey.en_US
dc.description.abstract[Ozdamar, Saim] Pamukkale Univ, Dept Histol & Embryol, Denizli, Turkey.en_US
dc.description.abstract[Yalcin, Betul; Karabulut, Derya] Erciyes Univ, Dept Histol & Embryol, Kayseri, Turkey.en_US
dc.language.isoenen_US
dc.publisherSOC ANATOMICA ESPANOLAen_US
dc.relation.ispartofEUROPEAN JOURNAL OF ANATOMYen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGFAP; Hippocampus; Subclinical hypothyroidism; IHC; MAP-2;en_US
dc.subjectPropylthiouracilen_US
dc.titleChanges in MAP-2 and GFAP immunoreactivity in pup hippocampus during prepubertal and pubertal periods caused by maternal subclinical hypothyroidismen_US
dc.typeArticleen_US
dc.identifier.volume23en_US
dc.identifier.issue1en_US
dc.identifier.startpage27
dc.identifier.startpage27en_US
dc.identifier.endpage40en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.wosWOS:000460700300004en_US
dc.identifier.scopusqualityQ4-
dc.ownerPamukkale University-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeArticle-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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