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https://hdl.handle.net/11499/34861
Title: | The Relationship Between Serum Endocan Level and Aortic Elastic Properties in Patients With Newly Diagnosed Essential Hypertension. | Authors: | Çelik, Mustafa Sökmen, Erdoğan Sivri, Serkan Uçar C Nar, Rukiye Erer M |
Keywords: | Adult; Aorta/*diagnostic imaging/physiopathology; Biomarkers/blood; *Blood Pressure; Case-Control Studies; Cross-Sectional Studies; *Echocardiography, Doppler, Pulsed; Elasticity; Essential Hypertension/blood/*diagnostic imaging/physiopathology; Female; Humans; Male; Middle Aged; Neoplasm Proteins/*blood; Predictive Value of Tests; Prognosis; Prospective Studies; Proteoglycans/*blood; Up-Regulation; *Vascular Stiffness | Abstract: | Endothelial dysfunction plays role in the generation of both essential hypertension (EH) and aortic stiffness. We evaluated the relationship between serum endocan level and aortic elastic properties (AEPs) assessed with the aortic strain, aortic distensibility, and aortic stiffness index by echocardiography. Newly diagnosed EH patients (n = 67) and controls (n = 70) were included in the study. The EH group was subdivided into stage 1 and 2 EH groups. A higher endocan level was found in the EH group, compared to the controls (34.2 ± 13.0 vs 24.1 ± 7.3 ng/mL, respectively, P < .001). All the AEP parameters were worse in the EH group, compared to the controls. Further, endocan levels correlated with aortic distensibility (r = -0.305, P < .001) and aortic strain (r = -0.181, P = .038), but not with aortic stiffness index (r = 0.162, P = .064) in the whole study population. Aortic elastic properties deteriorate and serum endocan level increases in patients with EH. Moreover, serum endocan level shows a correlation with deteriorated AEPs, and hence may a surrogate marker of escalating aortic stiffness in patients with newly diagnosed EH. | URI: | https://hdl.handle.net/11499/34861 https://doi.org/10.1177/0003319718823625 |
ISSN: | 1940-1574 0003-3197 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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