Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/34955
Title: Favourable effect of ß-glucan treatment against cisplatin-induced reproductive system damage in male rats.
Authors: Kaya, K.
Çiftçi, Osman
Aydın, M.
Çetin, A
Başak, N.
Keywords: Animals; Antineoplastic Agents/*adverse effects; Antioxidants/*administration & dosage; Cisplatin/*adverse effects; Disease Models, Animal; Epididymis/drug effects/pathology; Humans; Lipid Peroxidation/drug effects; Male; Oxidative Stress/drug effects; Rats; Rats, Sprague-Dawley; Sperm Count; Sperm Motility/drug effects; Testicular Diseases/chemically induced/pathology/*prevention & control; Testis/drug effects/pathology; Thiobarbituric Acid Reactive Substances/metabolism; beta-Glucans/*administ
Abstract: The aim of this study was to investigate the potential beneficial effects of ß-glucan treatment against oxidative, histological and spermatological damage caused by cisplatin on the male reproductive system. Twenty-eight Sprague Dawley male rats were used in the study. The rats were randomly divided into four equal-sized groups: a control group, cisplatin group (7 mg/kg in a single-dose cisplatin administered intraperitoneally), ß-glucan group (ß-glucan given at a dose of 50 mg kg(-1) d(-1) for 14 day) and a cisplatin plus ß-glucan group (cisplatin and ß-glucan administered together at the same dose). Cisplatin administration induced an increase in the level of thiobarbituric acid-reactive substances, a lipid peroxidation indicator. It induced a decrease in enzymatic (superoxide dismutase, catalase and glutathione peroxidase) activities and nonenzymatic (reduced glutathione) antioxidant levels. In addition, cisplatin caused both histological and spermatological damage, as shown by a decrease in sperm motility and epididymal sperm concentrations and an increase in abnormal sperm rates. The ß-glucan treatment improved cisplatin-induced oxidative, histological and spermatological damage. This study revealed that ß-glucan treatment provided prevention against male reproductive system damage caused by cisplatin. These preventative effects were likely due to its antioxidant properties.
URI: https://hdl.handle.net/11499/34955
https://doi.org/10.1111/and.13342. Epub 2019 Jul 5.
ISSN: 1439-0272
0303-4569
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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