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https://hdl.handle.net/11499/34959
Title: | MYC-driven regulation of long non-coding RNA profiles in breast cancer cells | Authors: | Tokgun, Pervin Elvan Tokgun, Onur Kurt, Serap Tomatir, Ayşe Gaye Akca, Hakan |
Keywords: | Breast Neoplasms/*genetics/pathology; Carcinogenesis/genetics; Cell Line, Tumor; Cell Proliferation/genetics; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Oncogenes; Proto-Oncogene Proteins c-myc/biosynthesis/*genetics; RNA, Long Noncoding/*genetics | Abstract: | AIM: MYC deregulation contributes to breast cancer development and progression. Deregulated expression levels of long non-coding RNAs (lncRNA) have been demonstrated to be critical players in development and/or maintenance of breast cancer. In this study we aimed to evaluate lncRNA expressions depending on MYC overexpression and knockdown in breast cancer cells. MATERIALS AND METHODS: Cells were infected with lentiviral vectors by either knockdown or overexpression of c-MYC. LncRNA cDNA was transcribed from total RNA samples and lncRNAs were evaluated by qRT-PCR. RESULTS: Our results indicated that some of the lncRNAs having tumor suppressor (GAS5, MEG3, lincRNA-p21) and oncogenic roles (HOTAIR) are regulated by c-MYC. CONCLUSION: We observed that c-MYC regulates lncRNAs that have important roles on proliferation, cell cycle and etc. Further studies will give us a light to identify molecular mechanisms related to MYC-lncRNA regulatory pathways in breast cancer. | URI: | https://hdl.handle.net/11499/34959 https://doi.org/10.1016/j.gene.2019.143955. Epub 2019 Jul 18. |
ISSN: | 1879-0038 0378-1119 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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