Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/35036
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dc.contributor.authorAcıpayam C-
dc.contributor.authorGüneş H-
dc.contributor.authorGüngör, Olcay-
dc.contributor.authorİpek S-
dc.contributor.authorSarışık N-
dc.contributor.authorDemir NŞ-
dc.date.accessioned2020-06-10T08:58:56Z
dc.date.available2020-06-10T08:58:56Z
dc.date.issued2020-
dc.identifier.issn1440-1754-
dc.identifier.issn1034-4810-
dc.identifier.urihttps://hdl.handle.net/11499/35036-
dc.identifier.urihttps://doi.org/10.1111/jpc.14733-
dc.description.abstractAIM: Nutritional B12 deficiency is a treatable cause of neurodevelopmental delay in infants. We report 21 infants with developmental regression and brain atrophy as revealed using cranial magnetic resonance imaging (MRI), secondary to severe vitamin B12 deficiency. METHODS: Twenty-one infants aged 4-24 months with B12 deficiencies who were admitted to our clinic between May 2013 and May 2018 were included in the study. MRI, bone marrow aspiration and the Denver-II Developmental Screening Test were performed in all infants. RESULTS: The mean age of the infants was 12.3 months, and the mean B12 level was 70.15 ± 32.15 ng/L. Hypotonia and neurodevelopmental retardation, and anaemia were present in all patients. Their bone marrow examinations were compatible with megaloblastic anaemia. Twelve patients had microcephaly, seven had tremor and one patient died of severe sepsis. Almost all patients were fed with breast milk and their mothers were also malnourished. Nine (42.9%) of the patients were Turkish and 12 (57.1%) were Syrian. All patients had abnormal Denver-II Developmental Screening Test scores. Most patients had severe cortical atrophy, cerebral effusion, thinning of the corpus callosum and delayed myelinisation in cranial MRI. Treatment with B12 resulted in dramatic improvement in general activity and appetite within 72 h. Tremors resolved in all cases. CONCLUSION: Neurological findings and developmental delay related to nutritional B12 deficiency can be prevented without sequelae if diagnosed early. Screening and treating of mothers for this deficiency will contribute to the health of both the mother and their feeding infant.en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of paediatrics and child healthen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleCerebral atrophy in 21 hypotonic infants with severe vitamin B12 deficiency.en_US
dc.typeArticleen_US
dc.identifier.volume56en_US
dc.identifier.issue5en_US
dc.identifier.startpage751-756
dc.identifier.startpageLID - 10.1111/jpc.14733 [doi]
dc.identifier.startpage751en_US
dc.identifier.endpage756en_US
dc.identifier.endpageLIDen_US
dc.identifier.doi10.1111/jpc.14733-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid31868292en_US
dc.identifier.scopus2-s2.0-85076898204en_US
dc.identifier.wosWOS:000503973500001en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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