Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/36523
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dc.contributor.authorUğur A-
dc.contributor.authorGültekin, Aziz-
dc.date.accessioned2021-02-02T09:16:49Z
dc.date.available2021-02-02T09:16:49Z
dc.date.issued2020-
dc.identifier.issn1874-4729-
dc.identifier.issn1874-4710-
dc.identifier.urihttps://hdl.handle.net/11499/36523-
dc.identifier.urihttps://doi.org/10.2174/1874471013666200421114031-
dc.description.abstractGallium-68 is an ideal research and hospital-based PET radioisotope. The uptake mechanism of Gallium citrate is a combination of specific and non-specific processes, for example, vasodilatation, increased vascular permeability, plasma transferrin binding and lactoferrin and siderophores. In this study, by applying the (68)Ge/(68)Ga generator product, a simple technique for the synthesis and quality control of (68)Ga-citrate was introduced and was followed by preliminary animal studies. The synthesis of (68)Ga-citrate was performed with a cationic method using the Scintomics automated synthesis system (Scintomics GmbH GRP module 4V). Since the standard procedure for quality control (QC) was not available, the definition of chemical and radiochemical purity of (68)Ga-citrate was carried out according to the ICH Q2(R1) guideline. The standard QC tests were analysed with Scintomics 8100 radio-HPLC system equipped with a radioactivity detector. In this study, a New Zealand rabbit weighing 2520 g was used for PET/CT images. (68)Ga-citrate synthesis was performed by a cationic method without using organic solvents. The labelling efficiency was found to be >98%. The HPLC method used to assess the radiochemical purity of (68)Ga -citrate was validated as rapid, accurate and reproducible enough to apply it to patients safely. The physiological distribution of (68)Ga-citrate was investigated in a healthy rabbit. The blood pool, liver, spleen, kidneys and growth plates were the most common sites of (68)Ga-citrate involvement.en_US
dc.language.isoenen_US
dc.relation.ispartofCurrent radiopharmaceuticalsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titlePhysiological Animal Imaging with 68Ga-Citrate.en_US
dc.typeArticleen_US
dc.authorid0000-0002-0311-8077-
dc.identifier.doi10.2174/1874471013666200421114031-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid32316906en_US
dc.identifier.scopus2-s2.0-85099435893en_US
dc.identifier.wosWOS:000641557600008en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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