Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/36873
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kılıç, Derya | - |
dc.contributor.author | Güler, Tolga | - |
dc.contributor.author | Atigan, A. | - |
dc.contributor.author | Avşaroğlu, Elif | - |
dc.contributor.author | Karakaya, Yeliz Arman | - |
dc.contributor.author | Kaleli, İlknur | - |
dc.contributor.author | Kaleli, Mehmet Babür | - |
dc.date.accessioned | 2021-02-02T09:23:10Z | - |
dc.date.available | 2021-02-02T09:23:10Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1092-9134 | - |
dc.identifier.uri | https://hdl.handle.net/11499/36873 | - |
dc.identifier.uri | https://doi.org/10.1016/j.anndiagpath.2020.151626 | - |
dc.description.abstract | Objective: This study aimed to determine the factors associated with Human Papillomavirus (HPV) persistence in women undergoing cervical excision for pre-invasive lesions, after they have been referred from a primary HPV screening program. Methods: A retrospective study design involving patients who were treated at a Cervical Disease Screening and Treatment Unit, in a university hospital setting. After initial treatment, cervical HPV infection status was analyzed at the sixth month, first year and then subsequently after the second year. Results: Totally, 395 patients who were diagnosed with pre-invasive cervical lesions and who subsequently undergone cervical excision were identified. In the first-year visit after cervical excision, HPV 18 was cleared in almost all (95.8%) cases, followed by HPV 16 (69.9%) and other hrHPV types (65.6%). Available data documented that 88.6% of women reached clearance after the two-year follow-up. Univariate analysis revealed a significantly higher proportion of HPV clearance among women who were younger (p = 0.019), premenopausal (p = 0.002), and who had been found to have a negative cytology result on their initial Pap test (p = 0.018). However, only cervical cytology result remained as the independent predictor of HPV persistence on a multivariate logistic regression (OR 0.43; 95% CI 0.21–0.87; p = 0.019). Conclusions: A low risk of HPV persistence was found among every HPV genotype in women undergoing cervical excision for pre-invasive cervical lesions. Initial cervical cytology result was the only independent predictor of HPV clearance during surveillance, which indicates the prognostic value of Pap test in primary HPV screening. © 2020 Elsevier Inc. | en_US |
dc.language.iso | en | en_US |
dc.publisher | W.B. Saunders | en_US |
dc.relation.ispartof | Annals of Diagnostic Pathology | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Cervical intraepithelial neoplasia | en_US |
dc.subject | Conization | en_US |
dc.subject | Human papillomavirus | en_US |
dc.subject | Persistence | en_US |
dc.subject | adult | en_US |
dc.subject | age | en_US |
dc.subject | aged | en_US |
dc.subject | Article | en_US |
dc.subject | cancer grading | en_US |
dc.subject | cancer patient | en_US |
dc.subject | cancer prognosis | en_US |
dc.subject | cancer surgery | en_US |
dc.subject | cohort analysis | en_US |
dc.subject | colposcopy | en_US |
dc.subject | disease association | en_US |
dc.subject | electrosurgery | en_US |
dc.subject | female | en_US |
dc.subject | follow up | en_US |
dc.subject | human | en_US |
dc.subject | Human papillomavirus type 16 | en_US |
dc.subject | Human papillomavirus type 18 | en_US |
dc.subject | Human papillomavirus type 31 | en_US |
dc.subject | Human papillomavirus type 33 | en_US |
dc.subject | Human papillomavirus type 35 | en_US |
dc.subject | Human papillomavirus type 39 | en_US |
dc.subject | Human papillomavirus type 45 | en_US |
dc.subject | Human papillomavirus type 51 | en_US |
dc.subject | Human papillomavirus type 52 | en_US |
dc.subject | Human papillomavirus type 56 | en_US |
dc.subject | Human papillomavirus type 58 | en_US |
dc.subject | Human papillomavirus type 59 | en_US |
dc.subject | Human papillomavirus type 66 | en_US |
dc.subject | Human papillomavirus type 68 | en_US |
dc.subject | independent variable | en_US |
dc.subject | loop electrosurgical excision procedure | en_US |
dc.subject | major clinical study | en_US |
dc.subject | mass screening | en_US |
dc.subject | nonhuman | en_US |
dc.subject | Papanicolaou test | en_US |
dc.subject | papillomavirus infection | en_US |
dc.subject | patient referral | en_US |
dc.subject | persistent virus infection | en_US |
dc.subject | predictor variable | en_US |
dc.subject | premenopause | en_US |
dc.subject | priority journal | en_US |
dc.subject | retrospective study | en_US |
dc.subject | risk factor | en_US |
dc.subject | university hospital | en_US |
dc.subject | uterine cervix carcinoma in situ | en_US |
dc.subject | uterine cervix conization | en_US |
dc.subject | uterine cervix cytology | en_US |
dc.subject | viral clearance | en_US |
dc.subject | Wart virus | en_US |
dc.title | Predictors of Human papillomavirus (HPV) persistence after treatment of high grade cervical lesions; does cervical cytology have any prognostic value in primary HPV screening? | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 49 | en_US |
dc.authorid | 0000-0001-8003-9586 | - |
dc.authorid | 0000-0001-6673-8604 | - |
dc.authorid | 0000-0002-6669-9972 | - |
dc.identifier.doi | 10.1016/j.anndiagpath.2020.151626 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 33011494 | en_US |
dc.identifier.scopus | 2-s2.0-85091969485 | en_US |
dc.identifier.wos | WOS:000601309200010 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale University | - |
item.openairetype | Article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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