Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/36904
Title: Intra-coronary Imaging for the Evaluation of Plaque Modifications Induced by Drug Therapies for Secondary Prevention
Authors: Kılıç, İsmail Doğu
Fabris, E.
Kedhi, E.
Ghilencea, L.-N.
Caiazzo, G.
Sherif, S.A.
Di Mario, C.
Keywords: Coronary artery disease
Coronary atherosclerosis
Intra-coronary imaging
Secondary prevention
Vulnerable plaque
high density lipoprotein
hydroxymethylglutaryl coenzyme A reductase inhibitor
proprotein convertase subtilisin kexin type 9 serine protease inhibitor
serine proteinase inhibitor
unclassified drug
apheresis
atherosclerotic plaque
coronary artery disease
drug effect
evaluation study
high risk patient
human
imaging
intra coronary imaging
ischemic heart disease
lipid apheresis
local therapy
Review
secondary prevention
systemic therapy
Publisher: Springer
Abstract: Purpose of Review: Patients diagnosed with coronary artery disease are at a high risk of subsequent cardiovascular events; therefore, secondary prevention in the form of therapeutic lifestyle changes, and drug therapies is vital. This article aims to review potential application of intra-coronary imaging for the evaluation of plaque modifications, induced by medications for secondary prevention for CAD. Recent Findings: Intra-coronary imaging provides detailed information on the atherosclerotic plaque which is the primary pathological substrate for the recurrent ischemic cardiovascular events. These modalities can detect features associated with high risk and allow serial in vivo imaging of lesions. Therefore, intravascular imaging tools have been used in landmark studies and played a role in improving our understanding of the disease processes. Summary: Changes in size and plaque composition over time can be evaluated by these tools and may help understanding the impact of a treatment. Moreover, surrogate imaging end points can be used when testing new drugs for secondary prevention. © 2020, The Author(s).
URI: https://hdl.handle.net/11499/36904
https://doi.org/10.1007/s11883-020-00890-4
ISSN: 1523-3804
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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