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https://hdl.handle.net/11499/36966
Title: | Succinivibrionaceae is dominant family in fecal microbiota of Behçet’s Syndrome patients with uveitis | Authors: | Tecer, D. Gogus, F. Kalkanci, A. Erdogan, M. Hasanreisoglu, M. Ergin, Çağrı Karakan, T. |
Keywords: | azathioprine colchicine cyclosporine genomic DNA HLA B51 antigen infliximab mesalazine methotrexate RNA 16S salazosulfapyridine steroid 6S rRNA gene adult Article autoinflammatory disease Bacteroides Behcet disease case control study clinical article controlled study Crohn disease DNA isolation familial Mediterranean fever feces microflora female gene sequence human human tissue immunopathogenesis innate immunity intestine flora male microbial community microbiological examination nonhuman prognosis semiconductor sequencing Succinivibrionaceae uveitis complication feces Gram negative infection isolation and purification microbiology Adult Behcet Syndrome Feces Female Gram-Negative Bacterial Infections Humans Male Uveitis |
Publisher: | Public Library of Science | Abstract: | Behçet’s Syndrome (BS) is a multisystem vasculitis with various clinical manifestations. Pathogenesis is unclear, but studies have shown genetic factors, innate immunity and autoinflammation to have an important role in the disease course. Diversity in the microbial community of gut microbiota may significantly contribute to the activation of the innate immune system. The clinical features of BS present themselves in clusters and each cluster may be a consequence of different disease mechanisms. For this reason we aimed to investigate the gut microbiota of BS patients with uveitis. In addition to healthy controls, we have aimed to compare the gut microbiota of BS with that of Familial Mediterranean Fever (FMF) and Crohn’s Disease (CD) as both diseases have innate and autoinflammatory features in their pathogenesis. Seven patients with BS, 12 patients with FMF, 9 patients with CD and 16 healthy controls (HC) were included in the study. Total genomic DNAs were isolated from fecal samples of the patients. Partial 16S rRNA gene was sequenced using the PGM Ion Torrent (Thermo Fisher Scientific, Waltham, MA, USA) for microbiota analysis. Statistical analysis showed that significant differences were detected on the microbial community of four groups. Succinivibrionaceae is dominant and the signature family, whereas Bacteroides was absent in BS patients. Copyright: © 2020 Tecer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | URI: | https://hdl.handle.net/11499/36966 https://doi.org/10.1371/journal.pone.0241691 |
ISSN: | 1932-6203 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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