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https://hdl.handle.net/11499/37009
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DC Field | Value | Language |
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dc.contributor.author | Yaylalı, Yalın Tolga | - |
dc.contributor.author | Yılmaz, Samet | - |
dc.contributor.author | Akgün-Cağlıyan, Gülsüm | - |
dc.contributor.author | Kılıç, Oğuz | - |
dc.contributor.author | Kaya, E. | - |
dc.contributor.author | Senol, H. | - |
dc.contributor.author | Özen, Furkan | - |
dc.date.accessioned | 2021-02-02T09:23:36Z | - |
dc.date.available | 2021-02-02T09:23:36Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1011-7571 | - |
dc.identifier.uri | https://hdl.handle.net/11499/37009 | - |
dc.identifier.uri | https://doi.org/10.1159/000506596 | - |
dc.description.abstract | Background: Pulmonary hypertension (PH) can complicate the course of myeloproliferative neoplasms (MPNs). Echocardiography is a useful noninvasive screening test for PH in populations at risk. We aimed to investigate the echocardiographic evidence of PH and clinical characteristics of patients with MPNs. Methods: This study included 197 patients with MPNs (mean age, 59 ± 14 years; females, 53%; mean disease duration, 3.4 ± 2.8 years). Clinical and laboratory characteristics, including JAK2V617F mutation status, were obtained. All participants underwent a comprehensive transthoracic echocardiographic examination. The echocardiographic evidence of PH was defined as systolic pulmonary artery pressure (SPAP) ?40 mm Hg. Results: Overall, 11 patients (5.5%) with SPAP ?40 mm Hg had echocardiographic evidence of PH. Patients with myelofibrosis had echocardiographic evidence of PH more often than patients with other MPNs (p < 0.001). Disease duration since the diagnosis of MPNs was 6.7 ± 4.6 years in the PH group and 3.1 ± 2.5 years in the non-PH group (p < 0.001). There was a weak positive correlation between SPAP values and time since diagnosis (r = 0.236, p =0.001). JAK2V617F mutation was not associated with PH. In multivariate logistic regression analysis, the presence of myelofibrosis (odds ratio [OR]: 22.177, 95% CI: 4.480-109.790, p < 0.001), long disease duration (OR: 1.217, 95% CI: 1.024-1.447, p = 0.026), and high uric acid levels (OR: 1.868, 95% CI: 1.049-3.328, p = 0.034) were found to be related with the echocardiographic evidence of PH. Survival was worse in the PH group (p = 0.0001). Conclusion: Our results suggest that patients with myelofibrosis are more likely to develop PH than other MPNs patients. Disease duration may predict the development of PH in MPN patients. © 2020 S. Karger AG. All rights reserved. | en_US |
dc.language.iso | en | en_US |
dc.publisher | S. Karger AG | en_US |
dc.relation.ispartof | Medical Principles and Practice | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | hemoglobin | en_US |
dc.subject | uric acid | en_US |
dc.subject | adult | en_US |
dc.subject | Article | en_US |
dc.subject | cancer diagnosis | en_US |
dc.subject | computer assisted tomography | en_US |
dc.subject | controlled study | en_US |
dc.subject | correlational study | en_US |
dc.subject | disease association | en_US |
dc.subject | disease duration | en_US |
dc.subject | female | en_US |
dc.subject | follow up | en_US |
dc.subject | human | en_US |
dc.subject | lung artery pressure | en_US |
dc.subject | major clinical study | en_US |
dc.subject | male | en_US |
dc.subject | middle aged | en_US |
dc.subject | myelofibrosis | en_US |
dc.subject | myeloproliferative neoplasm | en_US |
dc.subject | pulmonary hypertension | en_US |
dc.subject | pulmonologist | en_US |
dc.subject | retrospective study | en_US |
dc.subject | transthoracic echocardiography | en_US |
dc.subject | tricuspid regurgitation velocity | en_US |
dc.title | Association of Disease Subtype and Duration with Echocardiographic Evidence of Pulmonary Hypertension in Myeloproliferative Neoplasm | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 29 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 486 | - |
dc.identifier.startpage | 486 | en_US |
dc.identifier.endpage | 491 | en_US |
dc.authorid | 0000-0002-8452-923X | - |
dc.authorid | 0000-0002-8445-1911 | - |
dc.authorid | 0000-0001-6395-7924 | - |
dc.identifier.doi | 10.1159/000506596 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 32069470 | en_US |
dc.identifier.scopus | 2-s2.0-85088372534 | en_US |
dc.identifier.wos | WOS:000567965000012 | en_US |
dc.identifier.scopusquality | Q3 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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506596.pdf | 394.81 kB | Adobe PDF | View/Open |
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