Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/37019
Title: Novel ruthenium and palladium complexes as potential anticancer molecules on SCLC and NSCLC cell lines
Authors: Tokgun, O.
Karakas, D.E.
Tan, Semih
Karagür, E.R.
İnal, B.
Akca, H.
Durap, F.
Keywords: Bax
NSCLC
p21
Palladium
Phosphinite
Ruthenium
SCLC
Publisher: Springer
Abstract: Lung cancer is one of the major causes of cancer-related deaths in the world. Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer, and small-cell lung cancer (SCLC) is the most aggressive subtype of lung cancer. Proper therapies for SCLC have not yet been developed. However, new molecules have been designed and big innovation in treating SCLC has been achieved. Platinum-based antitumor drugs like cisplatin and carboplatin have several disadvantages including side effects, cisplatin-resistant tumors and limited solubility in aqueous media. Thus, two novel chiral aminoalcohol-based bis(phosphinite) ligands containing (?6-p-cymene)-Ru(II)-phosphinite and bis(phosphinite)–Pd(II) complexes were synthesized and evaluated for anticancer activity. In this study, the results showed that complex 1 has the strongest cytotoxic effects on SCLC and NSCLC cell lines. On the other hand, cisplatin, ruthenium and palladium complexes are capable to induce apoptosis. Especially, complexes 1 and 2 can induce apoptosis for both SCLC and NSCLC. When compared to the qRT-PCR and TUNEL results, we obtained a significant correlation between apoptotic index and p21, Bax gene expressions. This work revealed the potential of the synthesized complexes as anticancer agents with cytotoxic and pro-apoptotic activity as leading compounds for further anticancer researches. © 2020, Institute of Chemistry, Slovak Academy of Sciences.
URI: https://hdl.handle.net/11499/37019
https://doi.org/10.1007/s11696-020-01129-x
ISSN: 0366-6352
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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