Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/37051
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dc.contributor.authorSoylu, K.-
dc.contributor.authorCerik, I.B.-
dc.contributor.authorAksan, G.-
dc.contributor.authorNar, Gökay-
dc.contributor.authorMeric, M.-
dc.date.accessioned2021-02-02T09:23:46Z
dc.date.available2021-02-02T09:23:46Z
dc.date.issued2020-
dc.identifier.issn1880-4276-
dc.identifier.urihttps://hdl.handle.net/11499/37051-
dc.identifier.urihttps://doi.org/10.1002/joa3.12398-
dc.description.abstractObjectives: Ivabradine is a pharmacological agent used in patients with heart failure and sinus rhythm. Its only known pharmacological effect is to slow the heart rate. In this study, we investigated the impact of ivabradine on dyssynchrony parameters in heart failure patients. Methods: In this study, we assigned 55 patients taking medication for heart failure to receive ivabradine in addition (Group I). Twenty healthy volunteers comprised Group II. Echocardiographic measurements (dyssynchrony, left ventricular volumes and left ventricular ejection fraction) were taken at baseline, 1 month, and 3 months. Results: A total of 32 heart failure patients in Group I completed the study. There was significant improvement in dyssynchrony parameters after ivabradine treatment in Group I. Interventricular dyssynchrony (IVD) decreased from 42.0 ± 24.4 milliseconds at baseline to 33.6 ± 20.7 milliseconds at 1 month (P =.001) and to 30.7 ± 19.4 milliseconds at 3 months (P <.001). Septal to posterior wall motion delay decreased from 90.3 ± 21.4 milliseconds to 83.9 ± 26.9 milliseconds (P =.011) at 1 month and to 81.5 ± 27.3 milliseconds at 3 months (P =.001). Septal to lateral Ts delay (Ts-SL) decreased from 42.7 ± 24.5 milliseconds to 35.8 ± 22.6 milliseconds at 1 month (P <.001) and to 34.8 ± 22.4 milliseconds at 3 months (P =.002). Left ventricular end-systolic volume (LVESV) decreased from 139.4 ± 42.2 mL to 135.3 ± 39.6 mL at 1 month (P =.006) and to 123.3 ± 39.5 mL at 3 months (P <.001). Conclusion: The addition of ivabradine to heart failure treatment improves cardiac dyssynchrony parameters in chronic systolic heart failure patients with sinus rhythm. © 2020 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of Japanese Heart Rhythm Societyen_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal of Arrhythmiaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdyssynchronyen_US
dc.subjectheart failureen_US
dc.subjectivabradineen_US
dc.subjectangiotensin receptor antagonisten_US
dc.subjectbeta adrenergic receptor blocking agenten_US
dc.subjectbisoprololen_US
dc.subjectcarvedilolen_US
dc.subjectclopidogrelen_US
dc.subjectdigoxinen_US
dc.subjectdipeptidyl carboxypeptidase inhibitoren_US
dc.subjectfurosemideen_US
dc.subjectmetoprololen_US
dc.subjectspironolactoneen_US
dc.subjectadulten_US
dc.subjectArticleen_US
dc.subjectatrial fibrillationen_US
dc.subjectbradycardiaen_US
dc.subjectcardiomyopathyen_US
dc.subjectcardiovascular parametersen_US
dc.subjectcontrolled studyen_US
dc.subjectdiastolic blood pressureen_US
dc.subjectdrug withdrawalen_US
dc.subjectechocardiographyen_US
dc.subjectheart diseaseen_US
dc.subjectheart left ventricle ejection fractionen_US
dc.subjectheart left ventricle enddiastolic volumeen_US
dc.subjectheart rateen_US
dc.subjectheart ventricle remodelingen_US
dc.subjecthospitalizationen_US
dc.subjecthumanen_US
dc.subjectleft ventricular dyssynchronyen_US
dc.subjectleft ventricular end systolic volumeen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmiddle ageden_US
dc.subjectobservational studyen_US
dc.subjectP waveen_US
dc.subjectpacemaker implantationen_US
dc.subjectprospective studyen_US
dc.subjectpulsed Doppler ultrasonographyen_US
dc.subjectQRS intervalen_US
dc.subjectsinus nodeen_US
dc.subjectsinus rhythmen_US
dc.subjectsystolic blood pressureen_US
dc.titleEvaluation of ivabradine in left ventricular dyssynchrony and reverse remodeling in patients with chronic heart failureen_US
dc.typeArticleen_US
dc.identifier.volume36en_US
dc.identifier.issue4en_US
dc.identifier.startpage762
dc.identifier.startpage762en_US
dc.identifier.endpage767en_US
dc.identifier.doi10.1002/joa3.12398-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid32782651en_US
dc.identifier.scopus2-s2.0-85087440848en_US
dc.identifier.wosWOS:000545327300001en_US
dc.identifier.scopusqualityQ3-
dc.ownerPamukkale University-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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