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https://hdl.handle.net/11499/37062
Title: | The acromegaly registry of ten different centers in Turkey | Authors: | Keskin, Ç. Demir, Ö. Karcı, A.Ç. Berker, D. Cantürk, Z. Yaylalı, Güzin Fidan Topsakal |
Keywords: | cabergoline growth hormone pegvisomant somatomedin C somatostatin derivative somatostatin receptor acromegaly adolescent adult aged Article clinical feature controlled study disease control female health center human longitudinal study macroadenoma major clinical study male microadenoma monotherapy multicenter study prevalence priority journal radiotherapy register remission retrospective study transsphenoidal surgery treatment outcome Turkey (republic) |
Publisher: | Churchill Livingstone | Abstract: | Objectives: To describe biochemical and clinical features, and therapeutic outcomes of acromegaly patients in Turkey. Methods: Retrospective multicenter epidemiological study of 547 patients followed in 10 centers of the Turkish Acromegaly registry. Results: A total of 547 acromegaly patients (55% female) with a median age of 41 was included in this study. Majority of patients had a macroadenoma (78%). Transsphenoidal surgery was performed as primary treatment in 92% of the patients (n = 503). Surgical remission rate was 39% (197/503) in all operated patients. Overall disease control was achieved in 70% of patients. Remission group were significantly older than non-remission group (p = .002). Patients with microadenomas had significantly higher remission rates than patients with macroadenomas (p < .001). Patients with microadenomas were significantly older at the time of diagnosis when compared to patients with macroadenomas (p < .001). Preoperative growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were significantly lower in the remission group (p < .001). Initial IGF-1 and GH levels were significantly higher in macroadenomas compared to microadenomas (p < .001). Medical treatment was administered as a second-line treatment (97%) in almost all patients without remission. Radiotherapy was preferred in 21% of the patients mostly as a third line treatment. Conclusions: This is one of the largest real life studies evaluating the epidemiological characteristics and treatment outcomes of patients with acromegaly who were followed in different centers in Turkey. Transsphenoidal surgery in the treatment of acromegaly still remains the most valid method. Medical treatment options may improve long-term disease outcomes in patients who cannot be controlled with surgical treatment (up to 70%). © 2020 Elsevier Ltd | URI: | https://hdl.handle.net/11499/37062 https://doi.org/10.1016/j.ghir.2020.101322 |
ISSN: | 1096-6374 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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