Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/37153
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dc.contributor.authorŞimşek, Fikri-
dc.contributor.authorComak, A.-
dc.contributor.authorAsik, M.-
dc.contributor.authorKuslu, D.-
dc.contributor.authorBalci, T.-
dc.contributor.authorUlutas, H.-
dc.contributor.authorKoroglu, R.-
dc.date.accessioned2021-02-02T09:24:15Z-
dc.date.available2021-02-02T09:24:15Z-
dc.date.issued2020-
dc.identifier.issn1119-3077-
dc.identifier.urihttps://hdl.handle.net/11499/37153-
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_2_19-
dc.description.abstractBackground: The most widely accepted approach nowadays in nodal staging of non-small cell lung cancer (NSCLC) is the combined use of 18-Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) and endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA). However, this approach may not be sufficient, especially for early stages. Aims: Our aim was to assess whether more satisfactory results can be obtained with standardized uptake value maximum lymph node/standardized uptake value mean mediastinal blood pool (SUVmax LN/SUVmean MBP), SUVmax LN/Primary tumor, or a novel cut-off value to SUVmax in this special group. Subjects and Methods: Patients with diagnosed NSCLC and underwent FDG-PET/CT were reviewed retrospectively. 168 LNs of 52 early stage NSCLC patients were evaluated. The LNs identified in surgery/pathology reports were found in the FDG-PET/CT images. Anatomic and metabolic parameters were measured. Statistical analysis was performed by using of MedCalc Statistical Software. Results: Regardless of LNs size; sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of SUVmax >2.5 were 91.5%, 65.9%, 58.2%, and 95.1%, respectively. Optimum cut-off value of SUVmax was >4.0. Sensitivity, specificity, PPV, and NPV were found as 81.0%, 90.0%, 81.0%, and 90.0% respectively. Optimum cut-off value of SUVmax LN/SUVmean MBP was >1.71. Sensitivity, specificity, PPV, and NPV were found as 94.7%, 80.0%, 71.1%, and 96.7%, respectively. Optimum cut-off value of SUVmax LN/Primary tumor was >0.28. Sensitivity, specificity, PPV, and NPV were found as 81.1%, 85.1%, 72.9% and 90.1%, respectively. Conclusion: SUVmax LN/SUVmean MBP >1.71 has higher PPV than currently used, with similar NPV and sensitivity. This can provide increase in the accuracy of combined approach. In this way, faster nodal staging/treatment decisions, cost savings for healthcare system and time saving of medical professionals can be obtained. © 2020 Nigerian Journal of Clinical Practice - Published by Wolters Kluwer - Medknow.en_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEBUS-TBNAen_US
dc.subjectFDG-PET/CTen_US
dc.subjectNSCLCen_US
dc.subjectstagingen_US
dc.subjectfluorodeoxyglucose f 18en_US
dc.subjectradiopharmaceutical agenten_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectcancer stagingen_US
dc.subjectdiagnostic imagingen_US
dc.subjectendoscopic ultrasonographyen_US
dc.subjectfemaleen_US
dc.subjectfine needle aspiration biopsyen_US
dc.subjecthumanen_US
dc.subjectlung tumoren_US
dc.subjectlymph nodeen_US
dc.subjectlymph node metastasisen_US
dc.subjectmaleen_US
dc.subjectmediastinumen_US
dc.subjectmetabolismen_US
dc.subjectmiddle ageden_US
dc.subjectmultimodal imagingen_US
dc.subjectnon small cell lung canceren_US
dc.subjectpathologyen_US
dc.titleIs FDG-PET/CT used correctly in the combined approach for nodal staging in NSCLC patients?en_US
dc.typeOtheren_US
dc.identifier.volume23en_US
dc.identifier.issue6en_US
dc.identifier.startpage842-
dc.identifier.startpage842en_US
dc.identifier.endpage847en_US
dc.identifier.doi10.4103/njcp.njcp_2_19-
dc.relation.publicationcategoryDiğeren_US
dc.identifier.pmid32525121en_US
dc.identifier.scopus2-s2.0-85086355404en_US
dc.identifier.wosWOS:000543398100016en_US
dc.identifier.scopusqualityQ3-
dc.ownerPamukkale University-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypeOther-
item.grantfulltextnone-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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