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https://hdl.handle.net/11499/37153
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DC Field | Value | Language |
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dc.contributor.author | Şimşek, Fikri | - |
dc.contributor.author | Comak, A. | - |
dc.contributor.author | Asik, M. | - |
dc.contributor.author | Kuslu, D. | - |
dc.contributor.author | Balci, T. | - |
dc.contributor.author | Ulutas, H. | - |
dc.contributor.author | Koroglu, R. | - |
dc.date.accessioned | 2021-02-02T09:24:15Z | - |
dc.date.available | 2021-02-02T09:24:15Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1119-3077 | - |
dc.identifier.uri | https://hdl.handle.net/11499/37153 | - |
dc.identifier.uri | https://doi.org/10.4103/njcp.njcp_2_19 | - |
dc.description.abstract | Background: The most widely accepted approach nowadays in nodal staging of non-small cell lung cancer (NSCLC) is the combined use of 18-Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) and endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA). However, this approach may not be sufficient, especially for early stages. Aims: Our aim was to assess whether more satisfactory results can be obtained with standardized uptake value maximum lymph node/standardized uptake value mean mediastinal blood pool (SUVmax LN/SUVmean MBP), SUVmax LN/Primary tumor, or a novel cut-off value to SUVmax in this special group. Subjects and Methods: Patients with diagnosed NSCLC and underwent FDG-PET/CT were reviewed retrospectively. 168 LNs of 52 early stage NSCLC patients were evaluated. The LNs identified in surgery/pathology reports were found in the FDG-PET/CT images. Anatomic and metabolic parameters were measured. Statistical analysis was performed by using of MedCalc Statistical Software. Results: Regardless of LNs size; sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of SUVmax >2.5 were 91.5%, 65.9%, 58.2%, and 95.1%, respectively. Optimum cut-off value of SUVmax was >4.0. Sensitivity, specificity, PPV, and NPV were found as 81.0%, 90.0%, 81.0%, and 90.0% respectively. Optimum cut-off value of SUVmax LN/SUVmean MBP was >1.71. Sensitivity, specificity, PPV, and NPV were found as 94.7%, 80.0%, 71.1%, and 96.7%, respectively. Optimum cut-off value of SUVmax LN/Primary tumor was >0.28. Sensitivity, specificity, PPV, and NPV were found as 81.1%, 85.1%, 72.9% and 90.1%, respectively. Conclusion: SUVmax LN/SUVmean MBP >1.71 has higher PPV than currently used, with similar NPV and sensitivity. This can provide increase in the accuracy of combined approach. In this way, faster nodal staging/treatment decisions, cost savings for healthcare system and time saving of medical professionals can be obtained. © 2020 Nigerian Journal of Clinical Practice - Published by Wolters Kluwer - Medknow. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wolters Kluwer Medknow Publications | en_US |
dc.relation.ispartof | Nigerian Journal of Clinical Practice | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | EBUS-TBNA | en_US |
dc.subject | FDG-PET/CT | en_US |
dc.subject | NSCLC | en_US |
dc.subject | staging | en_US |
dc.subject | fluorodeoxyglucose f 18 | en_US |
dc.subject | radiopharmaceutical agent | en_US |
dc.subject | adult | en_US |
dc.subject | aged | en_US |
dc.subject | cancer staging | en_US |
dc.subject | diagnostic imaging | en_US |
dc.subject | endoscopic ultrasonography | en_US |
dc.subject | female | en_US |
dc.subject | fine needle aspiration biopsy | en_US |
dc.subject | human | en_US |
dc.subject | lung tumor | en_US |
dc.subject | lymph node | en_US |
dc.subject | lymph node metastasis | en_US |
dc.subject | male | en_US |
dc.subject | mediastinum | en_US |
dc.subject | metabolism | en_US |
dc.subject | middle aged | en_US |
dc.subject | multimodal imaging | en_US |
dc.subject | non small cell lung cancer | en_US |
dc.subject | pathology | en_US |
dc.title | Is FDG-PET/CT used correctly in the combined approach for nodal staging in NSCLC patients? | en_US |
dc.type | Other | en_US |
dc.identifier.volume | 23 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 842 | - |
dc.identifier.startpage | 842 | en_US |
dc.identifier.endpage | 847 | en_US |
dc.identifier.doi | 10.4103/njcp.njcp_2_19 | - |
dc.relation.publicationcategory | Diğer | en_US |
dc.identifier.pmid | 32525121 | en_US |
dc.identifier.scopus | 2-s2.0-85086355404 | en_US |
dc.identifier.wos | WOS:000543398100016 | en_US |
dc.identifier.scopusquality | Q3 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.openairetype | Other | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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