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https://hdl.handle.net/11499/37181
Title: | Molecular identification of HIV-1 in the presence of hepatitis B virus and hepatitis C virus co-infections | Authors: | Sayan, M. Özgüler, M. Yıldırım, F.S. Yıldırmak, T. Gündüz, A. Dokuzoğuz, B. Çelen, M.K. İnan, Dilara Heper, Yasemin Ersöz, Gülden Karaoğlan, İlkay Ceran, Nurgül Deveci, Aydın Öztürk, Servet Özdemir, Özkan Hülya Akbulut, Ayhan Yazıcı, Saadet Şener, Alper Çağatay, Arif Atahan Ünal, Serhat Sayın Kutlu, Selda |
Keywords: | Co-infection Hepatitis B virus Hepatitis C virus HIV-1 Molecular epidemiology hepatitis B surface antigen nonnucleoside reverse transcriptase inhibitor proteinase proteinase inhibitor RNA directed DNA polymerase RNA directed DNA polymerase inhibitor adult Article controlled study cross-sectional study disease transmission enzyme linked immunosorbent assay female gene mutation gene sequence genotype hepatitis B hepatitis C human Human immunodeficiency virus infection infection risk laboratory test major clinical study male mixed infection molecular epidemiology polymerase chain reaction prevalence retrospective study Turkey (republic) virus detection virus gene virus resistance Western blotting |
Publisher: | Galenos Publishing House | Abstract: | Background: Because of their similar modes of transmission, the simultaneous infection of viral hepatitis and human immunodeficiency virus are increasingly seen as a big problem related to human health. Aims: To determine the drug mutations in hepatitis B virus and/or hepatitis C virus co-infected human immunodeficiency virus-1 patients in Turkey. Study Design: Retrospective cross-sectional study. Methods: The present study was conducted between 2010 and 2017. HBsAg, anti-hepatitis C virus, and anti-human immunodeficiency virus were tested with ELISA. All anti-human immunodeficiency virus positive results by ELISA were verified for anti-human immunodeficiency virus positivity by a Western blot test, and Anti-human immunodeficiency virus positive patients with HBsAg and/or anti-hepatitis C virus positivity were included in the study. Subtyping and genotypic resistance analyses were performed by population sequencing of the viral protease and reverse transcriptase regions of the human immunodeficiency virus-1 pol gene. Results: We detected 3896 human immunodeficiency virus-1 positive patients whose sera were sent from numerous hospitals across the country to our polymerase chain reaction unit for detection of drug resistance mutations and whose molecular laboratory tests were completed. Viral hepatitis co-infections were detected in 4.3% (n=170) of patients. Hepatitis B virus and hepatitis C virus co-infection were observed in 3.2% and 0.5% of all human immunodeficiency virus-1 infected patients, respectively. The major human immunodeficiency virus-1 subtype detected was group M, subtype B (62.9%). However, 13.5% of drug resistance mutation motifs were found in human immunodeficiency virus-1 genomes of patients included in the study. Conclusion: Due to similar transmission routes, HIV1 patients are at risk of hepatitis B and C virus co-infection. However, antiretroviral drug resistance mutation model is similar to patients with hepatitis negative. © 2020 by Trakya University Faculty of Medicine / The Balkan Medical Journal published by Galenos Publishing House. | URI: | https://hdl.handle.net/11499/37181 https://doi.org/10.4274/balkanmedj.galenos.2020.2019.5.89 |
ISSN: | 2146-3123 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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