Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/37181
Title: Molecular identification of HIV-1 in the presence of hepatitis B virus and hepatitis C virus co-infections
Authors: Sayan, M.
Özgüler, M.
Yıldırım, F.S.
Yıldırmak, T.
Gündüz, A.
Dokuzoğuz, B.
Çelen, M.K.
İnan, Dilara
Heper, Yasemin
Ersöz, Gülden
Karaoğlan, İlkay
Ceran, Nurgül
Deveci, Aydın
Öztürk, Servet
Özdemir, Özkan Hülya
Akbulut, Ayhan
Yazıcı, Saadet
Şener, Alper
Çağatay, Arif Atahan
Ünal, Serhat
Sayın Kutlu, Selda
Keywords: Co-infection
Hepatitis B virus
Hepatitis C virus
HIV-1
Molecular epidemiology
hepatitis B surface antigen
nonnucleoside reverse transcriptase inhibitor
proteinase
proteinase inhibitor
RNA directed DNA polymerase
RNA directed DNA polymerase inhibitor
adult
Article
controlled study
cross-sectional study
disease transmission
enzyme linked immunosorbent assay
female
gene mutation
gene sequence
genotype
hepatitis B
hepatitis C
human
Human immunodeficiency virus infection
infection risk
laboratory test
major clinical study
male
mixed infection
molecular epidemiology
polymerase chain reaction
prevalence
retrospective study
Turkey (republic)
virus detection
virus gene
virus resistance
Western blotting
Publisher: Galenos Publishing House
Abstract: Background: Because of their similar modes of transmission, the simultaneous infection of viral hepatitis and human immunodeficiency virus are increasingly seen as a big problem related to human health. Aims: To determine the drug mutations in hepatitis B virus and/or hepatitis C virus co-infected human immunodeficiency virus-1 patients in Turkey. Study Design: Retrospective cross-sectional study. Methods: The present study was conducted between 2010 and 2017. HBsAg, anti-hepatitis C virus, and anti-human immunodeficiency virus were tested with ELISA. All anti-human immunodeficiency virus positive results by ELISA were verified for anti-human immunodeficiency virus positivity by a Western blot test, and Anti-human immunodeficiency virus positive patients with HBsAg and/or anti-hepatitis C virus positivity were included in the study. Subtyping and genotypic resistance analyses were performed by population sequencing of the viral protease and reverse transcriptase regions of the human immunodeficiency virus-1 pol gene. Results: We detected 3896 human immunodeficiency virus-1 positive patients whose sera were sent from numerous hospitals across the country to our polymerase chain reaction unit for detection of drug resistance mutations and whose molecular laboratory tests were completed. Viral hepatitis co-infections were detected in 4.3% (n=170) of patients. Hepatitis B virus and hepatitis C virus co-infection were observed in 3.2% and 0.5% of all human immunodeficiency virus-1 infected patients, respectively. The major human immunodeficiency virus-1 subtype detected was group M, subtype B (62.9%). However, 13.5% of drug resistance mutation motifs were found in human immunodeficiency virus-1 genomes of patients included in the study. Conclusion: Due to similar transmission routes, HIV1 patients are at risk of hepatitis B and C virus co-infection. However, antiretroviral drug resistance mutation model is similar to patients with hepatitis negative. © 2020 by Trakya University Faculty of Medicine / The Balkan Medical Journal published by Galenos Publishing House.
URI: https://hdl.handle.net/11499/37181
https://doi.org/10.4274/balkanmedj.galenos.2020.2019.5.89
ISSN: 2146-3123
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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