Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/37212
Title: Does primary tumor localization has prognostic importance in seminoma patients?: Turkish oncology Group study
Authors: Yildiz, B
Kucukarda, A
Gokyer, A
Demiray, Atike Gökçen
Paydas, S
Aral, IP
Gumusay, O
Keywords: Germ cell tumor
Primary tumor localization
Prognosis
Seminoma
Survey
Testicular cancer
carboplatin
adult
aged
Article
cancer chemotherapy
cancer prognosis
cancer staging
cancer survival
follow up
human
major clinical study
male
overall survival
primary tumor
progression free survival
retrospective study
risk factor
seminoma
tumor localization
tumor recurrence
Publisher: Zerbinis Publications
Abstract: Purpose: The purpose of this study was to determine whether primary tumor localization may be a risk factor for relapse and survival in seminomatous germ cell tumors (GCT) patients. Methods: In our study, 612 seminomatous GCT patients diagnosed in 22 centers between 01.01.1989 and 03.02.2019 were retrospectively evaluated. Patient interview information, patient files and electronic system data were used for the study. Results: The primary tumor was localized in the right testis in 305 (49.9%) patients and in 307 (50.1%) in the left testis. Mean age of the patients was 36 years (range 16-85±10.4). The median follow-up period was 47 months (1-298). Recurrence was observed in 78 (12.7%) patients and 29 (4.7%) died during the follow-up period. Four-year overall survival (OS) was 95.4% and 4-year progression-free survival (PFS) was 84.5%. The relationship between localization and relapse was significant in 197 patients with stage 2 and stage 3 (p=0.003). In this patient group, 41 (20.8%) relapses were observed. Thirty (73.2%) of the relapses were in the right testis and 11 (26.8%) in the left testis. Four-year OS was 92.1% in patients with right tumor; and 98.7% in patients with left tumor (p=0.007). When 612 patients were evaluated with a mean follow-up of 4 years, there was a 6.6% survival advantage in patients with left testicular tumor and this difference was significant (p=0.007). Conclusion: Survival rates of patients with primary right testicular localization were worse compared with left testicular localization, and relapse rates were higher in stage 2 and 3 patients with right testicular localization. © 2020 Zerbinis Publications. All rights reserved.
URI: https://hdl.handle.net/11499/37212
ISSN: 1107-0625
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File SizeFormat 
25-2-1130.pdf1.12 MBAdobe PDFView/Open
Show full item record



CORE Recommender

SCOPUSTM   
Citations

1
checked on Dec 14, 2024

Page view(s)

46
checked on Aug 24, 2024

Download(s)

28
checked on Aug 24, 2024

Google ScholarTM

Check





Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.