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https://hdl.handle.net/11499/37274
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gülten, Gülsün | - |
dc.contributor.author | Yalçın, Nagihan | - |
dc.contributor.author | Baltalarlı, Bahar | - |
dc.contributor.author | Doğu, Gamze Gokoz | - |
dc.contributor.author | Acar, Feridun | - |
dc.contributor.author | Doğruel, Yücel | - |
dc.date.accessioned | 2021-02-02T09:24:53Z | |
dc.date.available | 2021-02-02T09:24:53Z | |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1233-9687 | - |
dc.identifier.uri | https://hdl.handle.net/11499/37274 | - |
dc.identifier.uri | https://doi.org/10.5114/pjp.2020.97020 | - |
dc.description.abstract | Numerous genetic pathways associated with glioblastoma development have been identified. In this study, we investigated the prognostic significance of IDH1 and ATRX mutations and WT-1 and p53 expression in glioblastomas and that of surgical methods, radiotherapy and chemotherapy. 83 patients with glioblastomas were retrospectively evaluated. Immunohistochemical analysis was performed for IDH1, ATRX and WT-1 expression. Tumour cells were positive for IDH1 in 9.6% of the patients. In 4.8% of the patients, loss of ATRX expression was observed in tumour cells; 86.7% of the patients were WT-1 positive, and 12.05% of the patients were p53 positive. No statistically significant difference was found in the progression-free and overall survival according to IDH1, ATRX, WT-1 and p53 expression. There was a statistically significant difference in the progression-free and overall survival according to the radiotherapy status. There was a statistically significant difference in the overall survival according to the chemotherapy status. There was no statistically significant difference in the progression-free and overall survival according to the surgical method. IDH1 and ATRX mutations, p53 overexpression and WT-1 expression alone did not have a significant effect on the prognosis of patients with glioblastoma; however, radiotherapy and chemotherapy had a positive effect on survival. © 2020, Termedia Publishing House Ltd.. All rights reserved. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Termedia Publishing House Ltd. | en_US |
dc.relation.ispartof | Polish Journal of Pathology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | ATRX | en_US |
dc.subject | Glioblastoma | en_US |
dc.subject | IDH1 | en_US |
dc.subject | Immunohistochemistry | en_US |
dc.subject | WT-1 | en_US |
dc.subject | ATRX protein, human | en_US |
dc.subject | IDH1 protein, human | en_US |
dc.subject | isocitrate dehydrogenase | en_US |
dc.subject | transcriptional regulator ATRX | en_US |
dc.subject | WT1 protein | en_US |
dc.subject | WT1 protein, human | en_US |
dc.subject | genetics | en_US |
dc.subject | glioblastoma | en_US |
dc.subject | human | en_US |
dc.subject | mutation | en_US |
dc.subject | prognosis | en_US |
dc.subject | retrospective study | en_US |
dc.subject | Humans | en_US |
dc.subject | Isocitrate Dehydrogenase | en_US |
dc.subject | Mutation | en_US |
dc.subject | Prognosis | en_US |
dc.subject | Retrospective Studies | en_US |
dc.subject | WT1 Proteins | en_US |
dc.subject | X-linked Nuclear Protein | en_US |
dc.title | The importance of idh1, atrx and wt-1 mutations in glioblastoma | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 71 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 127 | |
dc.identifier.startpage | 127 | en_US |
dc.identifier.endpage | 137 | en_US |
dc.authorid | infoeu-repo/semantics/openAccess | - |
dc.identifier.doi | 10.5114/pjp.2020.97020 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 32729303 | en_US |
dc.identifier.scopus | 2-s2.0-85088852836 | en_US |
dc.identifier.wos | WOS:000552141700006 | en_US |
dc.identifier.scopusquality | Q3 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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File | Size | Format | |
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PJP_Art_41206-10.pdf | 3.23 MB | Adobe PDF | View/Open |
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