Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/37470
Title: Analysis of survival of the patients with brain metastases from lung cancer according to treatment modalities and prognostic indexes
Authors: Sağınç, Halil
Baltalarli, P.B.
Keywords: Brain metastases
Lung cancer
Prognostic index
Survival
adult
aged
Article
Basic Score for Brain Metastases
brain metastasis
cancer chemotherapy
cancer control
cancer prognosis
cancer staging
cancer survival
cancer therapy
comparative study
computer assisted tomography
female
follow up
Graded Prognostic Assessment Index
human
Karnofsky Performance Status
lung cancer
major clinical study
male
metastasis resection
middle aged
non small cell lung cancer
nuclear magnetic resonance imaging
outcome assessment
overall survival
prognostic assessment
Recursive Partitioning Analysis Class
retrospective study
salvage therapy
scoring system
small cell lung cancer
survival analysis
survival rate
tumor volume
Publisher: Istanbul Tip Fakultesi
Abstract: OBJECTIVE This study aimed to retrospectively evaluate overall survival (OS) of the patients with brain metastases (BM) from lung cancer who had been treated with whole-brain radiotherapy (WBRT) and gamma knife (GK) according to prognostic factors and prognostic score indexes. METHODS Ninety-five patients with brain metastases from lung cancer were retrospectively evaluated using age, sex, lung cancer histological type, extracranial metastases, primary tumor control, number of brain metastases, total brain metastases volume, brain metastasectomy, chemotherapy, EGFR mutation, EGFR-TKI therapy, Karnofsky Performance Status (KPS), Recursive Partitioning Analysis (RPA) Class, Basic Score for Brain Metastases (BS-BM), Graded Prognostic Assessment Index (DS-GPA) and Modified Lung-Specific between 2015 and 2018. Univariate analysis of OS was performed using the Kaplan–Meier method supplemented by the log-rank test. We also applied multivariate survival analysis using the Cox Regression Model. RESULTS The median OS for all patients with brain metastases from lung cancer was six months± SE: 0.807 (range: 1–42 months; 95% CI: 4.419–7.581) and one-year overall survival rate was 25.3%. The median OS was four months, four months, 12 months in the WBRT arm, the GK arm and the combined WBRT-GK arm, respectively (p=0.004). In multivariate analysis, treatment with WBRT–GK (p=0.030), brain metastasectomy (p=0.019), controlled primary tumor (p=0.004), chemotherapy (p=0.001) were significantly correlated with overall survival. BS-BM (p=0.033) was closely related to overall survival compared to other prognostic score indexes on the multivariate analysis. CONCLUSION The patients with BM benefited from WBRT and GK combined therapy. BS-BM for the survival of patients with BM from lung cancer is the most appropriate prognostic index. © 2020, Turkish Society for Radiation Oncology.
URI: https://hdl.handle.net/11499/37470
https://doi.org/10.5505/tjo.2019.2101
ISSN: 1300-7467
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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