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https://hdl.handle.net/11499/37524
Title: | Genome-wide DNA methylation profiling of blood from monozygotic twins discordant for myocardial infarction | Authors: | Köseler, Aylin Ma, F. Kılıç, İsmail Doğu Morselli, M. Kilic, O. Pellegrini, M. |
Keywords: | Cardiovascular disease DNA methylation Epigenetics acyl coenzyme A synthetase family member 3 acyl coenzyme A synthetase medium chain family member 2A acyl coenzyme A synthetase medium chain family member 5 AFG3 like matrix AAA peptidase subunit 2 apolipoprotein B aspartate aminotransferase carboxylesterase 1 carboxylesterase 1 pseudogene 1 creatine kinase enzyme genomic DNA hydrolase iron sulfur cluster assembly enzyme lactate dehydrogenase lipid droplet associated hydrolase microsomal triglyceride transfer protein SEC14 like lipid binding 2 unclassified drug adult anterior myocardial infarction Article B lymphocyte blood case report cholesterol metabolism clinical article coronary artery obstruction CpG island echocardiography electrocardiography enzyme blood level fatty acid metabolism gene locus genetic background genome analysis human human cell male monocyte monozygotic twins multidetector computed tomography neutrophil percutaneous coronary intervention reduced representation bisulfite sequencing T lymphocyte twin discordance gene expression profiling gene expression regulation genetic epigenesis genetic marker genetics heart infarction human genome phenotype prognosis promoter region Adult DNA Methylation Epigenesis, Genetic Gene Expression Profiling Gene Expression Regulation Genetic Markers Genome, Human Humans Male Myocardial Infarction Phenotype Prognosis Promoter Regions, Genetic Twins, Monozygotic |
Publisher: | International Institute of Anticancer Research | Abstract: | Background/Aim: This study aimed to measure the DNA methylation state of thousands of CpG islands in the blood of two monozygotic twins that were discordant for cardiovascular disease (CVD). Twin 1 had suffered myocardial infarction, while the other was healthy. Patients and Methods: Since the aim of this study was to identify differentially methylated regions which might act as potential markers, reduced-representation bisulfite libraries were used for whole-genome methylation analysis. Results: According to the analysis, 11 genes lipid droplet associated hydrolase (LDAH), apolipoprotein B (APOB), acyl-CoA synthetase medium chain family member 2A (ACSM2A), acyl-CoA synthetase medium chain family member 5(ACSM5), acyl-CoA synthetase family member 3 (ACSF3), carboxylesterase 1 (CES1), carboxylesterase 1 pseudogene 1 (CES1P1), AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), iron-sulfur cluster assembly enzyme (ISCU), SEC14 like lipid binding 2 (SEC14L2) and microsomal triglyceride transfer protein (MTTP) were all hypomethylated in DNA from twin 2, the unaffected twin. Methylation changes were observed at different multiple loci between the twins, suggesting loci that are affected by disease status in identical genetic backgrounds. Conclusion: This twin study may contribute significantly to the understanding of the genetic basis of CVD and resulting myocardial infarction. This approach may allow identification of possible target loci associated with aberrant epigenetic regulation in CVD. © 2020 International Institute of Anticancer Research. All rights reserved. | URI: | https://hdl.handle.net/11499/37524 https://doi.org/10.21873/invivo.11782 |
ISSN: | 0258-851X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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