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https://hdl.handle.net/11499/4082
Title: | Influence of cadmium and copper on tissue element levels of pregnant rats | Authors: | Turgut, Sabahat. Enli, Y. Emmungil, Gülten Erken. Turgut, Günfer. Demir, S. Kaptanoglu, B. Genç, Osman. |
Keywords: | Cadmium Copper Fetus Pregnancy Rat cadmium copper iron zinc animal experiment article body weight controlled study female kidney function liver function maternal plasma nonhuman placenta placenta weight pregnancy priority journal rat |
Abstract: | In the current study, we examined the effects of Cd on Cd, Cu, Zn and Fe levels in placenta and maternal and fetal plasma and tissues, the placental weight, total fetal and maternal body weights, and fetal and maternal tissue weights during pregnancy. A total of 21 adult female rats were treated during gestation with drinking water containing one of the following: 70 mg/L of CdCl2, a combination of 70 mg/L of CdCl2 and 70 mg/L of CuSO4, or no addition (control). Placenta Cu and Fe levels, fetal liver and kidney Cu levels, and fetal liver tissue weights were lower in the group administered Cd than in the control group. Also, Cd levels in the placenta, maternal and fetal liver, and maternal kidney were higher in the group treated with Cd than in controls. In the group administered both Cd and Cu, fetal body and tissue weights did not change, but Cd levels in the placenta, maternal and fetal liver, and maternal kidneys were higher than in controls. Zn and Fe levels in the maternal kidney and fetal liver were also lower in this group. Cd exposure during pregnancy resulted in Cd accumulation in maternal and fetal tissues during pregnancy and a decrease in the total weight of fetuses, and the combination of Cd and Cu caused some changes in the both maternal and fetal levels of Cu, Zn, and Fe, but it did not cause changes in the total fetal body weight or the weights of individual tissues. © 2007 Versita Warsaw and Springer-Verlag. | URI: | https://hdl.handle.net/11499/4082 https://doi.org/10.2478/s11536-007-0047-x |
ISSN: | 1895-1058 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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[23915463 - Open Medicine].pdf | 171 kB | Adobe PDF | View/Open |
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