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https://hdl.handle.net/11499/4196
Title: | Effect of sulfur dioxide on active and passive avoidance in experimental diabetes mellitus: Relation to oxidant stress and antioxidant enzymes | Authors: | Küçükatay, Vural. A?ar, Aysel. Gümüşlü, Saadet. Yargıço?lu, Piraye. |
Keywords: | Active avoidance Antioxidant status Diabetes mellitus Passive avoidance SO2 TBARS alloxan antioxidant catalase copper zinc superoxide dismutase glutathione peroxidase lipid sulfur dioxide thiobarbituric acid reactive substance animal experiment animal model antioxidant activity article avoidance behavior controlled study diabetes mellitus disease association enzyme activity hippocampus learning learning disorder lipid peroxidation male memory memory disorder nonhuman oxidative stress passive avoidance rat training Air Pollutants Analysis of Variance Animals Avoidance Learning Blood Glucose Catalase Conditioning (Psychology) Diabetes Mellitus, Experimental Disease Models, Animal Eating Glutathione Peroxidase Hippocampus Lipid Peroxidation Male Rats Sulfur Dioxide Superoxide Dismutase Thiobarbituric Acid Reactive Substances Time Factors |
Abstract: | The effect of sulfur dioxide (SO2) on hippocampus antioxidant status, lipid peroxidation and learning and memory was investigated in diabetic rats. A total of 40 rats were divided into four equal groups: Control (C), SO2 + C (SO2), diabetic (DM) and SO2 + D (DMSO2). Experimental diabetes mellitus (DM) was induced by i.v injection of alloxan with a dose of 50 mg/kg body weight. Ten ppm SO2 was administered to the rats in the sulfur dioxide groups in an exposure chamber. Exposure occurred 1 h/d, 7 d/wk, for 6 wk; control rats were exposed to filtered air during the same time periods. SO2 exposure, while markedly increasing Cu-Zn Superoxide dismutase activity, significantly decreased glutathione peroxidase activity in diabetic and non-diabetic groups compared with the C group; hippocampus catalase activity was unaltered. Hippocampus thiobarbituric acid reactive substances (TBARS) were found to be elevated in all experimental groups with respect to control group. The active avoidance training results indicated that diabetic condition has been associated with learning and memory impairment. SO2 exposure caused deficits of learning and memory. Diabetes mellitus-induced impairment of learning and memory were potentiated by SO2 exposure. These findings suggest that exposure to SO2 by increasing lipid peroxidation, can change antioxidant enzyme activities and can elevated intensity of deficits of learning and memory in diabetic rats. Copyright © 2007 Informa Healthcare. | URI: | https://hdl.handle.net/11499/4196 https://doi.org/10.1080/00207450600934531 |
ISSN: | 0020-7454 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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