Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4218
Title: Genetic origin of Hb D-Los Angeles [ß121(GH4)Glu›Gln, GAA›CAA] according to the ß-globin gene cluster haplotypes
Authors: Atalay, Erol Ömer.
Atalay, Ayfer.
Üstel, E.
Yıldız, Sanem.
Öztürk, Onur.
Köseler, Aylin.
Bahadır, Ander.
Keywords: Genetic origin
Haplotypes
Hb D-Los Angeles
beta globin
glutamic acid
glutamine
hemoglobin d punjab
hemoglobin variant
unclassified drug
amino acid substitution
article
gene cluster
gene mutation
haplotype
heterozygosity
polymerase chain reaction
Turkey (republic)
Globins
Hemoglobins, Abnormal
Humans
Multigene Family
Population Dynamics
Turkey
Abstract: Hb D-Los Angeles (also known as D-Punjab, D-North Carolina, D-Portugal, D-Chicago and Oak Ridge) is an abnormal hemoglobin (Hb) with an amino acid substitution of glutamine for glutamic acid at codon 121 of the ß-globin gene. The origin and spread of Hb D-Los Angeles is not known. This is due to lack of information and remains to be elucidated. According to published reports, the Hb D-Los Angeles mutation is mostly linked with Mediterranean haplotype I [+ - - - - + +]. Besides the Mediterranean haplotype, a novel haplotype was also reported from Thailand [- - + + - - + + +]. Here we report a new haplotype from Turkey [- + - + + +] that has not been described before. These results suggest that the Hb D-Los Angeles mutation has at least three different genetic origins. Copyright © Informa Healthcare.
URI: https://hdl.handle.net/11499/4218
https://doi.org/10.1080/03630260701459416
ISSN: 0363-0269
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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