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https://hdl.handle.net/11499/4222
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Küçükatay, Vural. | - |
dc.contributor.author | Bor-Kucukatay, Melek | - |
dc.contributor.author | Atsak, Piray. | - |
dc.contributor.author | Agar, A. | - |
dc.date.accessioned | 2019-08-16T11:32:54Z | - |
dc.date.available | 2019-08-16T11:32:54Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0020-7454 | - |
dc.identifier.uri | https://hdl.handle.net/11499/4222 | - |
dc.identifier.uri | https://doi.org/10.1080/00207450600934085 | - |
dc.description.abstract | Animal tissues are exposed to sulfite used as a preservative in food and drugs, and generated from the catabolism of sulfur-containing amino acids. Sulfite, which is a very reactive and potentially toxic molecule, is detoxified by the enzyme sulfite oxidase (SOX). Laboratory animals can be made deficient in SOX by the administration of a high-tungsten/low molybdenum regimen. It has been suggested that SOX deficient rats might be used as a model for the prediction of sulfite toxicity in humans. The aim of this study was to investigate the effects of ingested sulfite on hippocampus superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in SOX competent and deficient rats. Hippocampus SOD, CAT and GPx activities were found to be significantly increased by sulfite treatment in SOX competent groups. On the other hand, exposure to sulfite had no effect on antioxidant status in hippocampus of SOX deficient rats. In conclusion, these results suggest that hippocampus antioxidant capacity where defense mechanism against the oxidative challenge is up regulated by sulfite in SOX competent rats. This up regulation mechanism in antioxidant enzymes against to sulfite related oxidative stress is not observed in SOX deficient rats and remains to be explained. Copyright © 2007 Informa Healthcare. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | International Journal of Neuroscience | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Food additives | en_US |
dc.subject | Free radicals | en_US |
dc.subject | Hippocampus | en_US |
dc.subject | Sulfite | en_US |
dc.subject | catalase | en_US |
dc.subject | enzyme | en_US |
dc.subject | glutathione peroxidase | en_US |
dc.subject | sulfite | en_US |
dc.subject | sulfite oxidase | en_US |
dc.subject | superoxide dismutase | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal tissue | en_US |
dc.subject | article | en_US |
dc.subject | controlled study | en_US |
dc.subject | defense mechanism | en_US |
dc.subject | enzyme activity | en_US |
dc.subject | hippocampus | en_US |
dc.subject | ingestion | en_US |
dc.subject | male | en_US |
dc.subject | nonhuman | en_US |
dc.subject | oxidative stress | en_US |
dc.subject | rat | en_US |
dc.subject | upregulation | en_US |
dc.subject | Administration, Oral | en_US |
dc.subject | Animals | en_US |
dc.subject | Antioxidants | en_US |
dc.subject | Catalase | en_US |
dc.subject | Enzyme Activation | en_US |
dc.subject | Food Preservatives | en_US |
dc.subject | Glutathione Peroxidase | en_US |
dc.subject | Male | en_US |
dc.subject | Rats | en_US |
dc.subject | Sulfite Oxidase | en_US |
dc.subject | Sulfites | en_US |
dc.subject | Superoxide Dismutase | en_US |
dc.subject | Up-Regulation | en_US |
dc.title | Effect of ingested sulfite on hippocampus antioxidant enzyme activities in sulfite oxidase competent and deficient rats | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 117 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.startpage | 971 | - |
dc.identifier.startpage | 971 | en_US |
dc.identifier.endpage | 983 | en_US |
dc.authorid | 0000-0002-6850-6281 | - |
dc.authorid | 0000-0002-9366-0205 | - |
dc.identifier.doi | 10.1080/00207450600934085 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 17613108 | en_US |
dc.identifier.scopus | 2-s2.0-34347383527 | en_US |
dc.identifier.wos | WOS:000247159200007 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale_University | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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