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https://hdl.handle.net/11499/4240
Title: | Frequency of mutated allele CYP2D6*4 in the Turkish population | Authors: | Köseler, Aylin Ilcol, Y.O. Ulus, I.H. |
Keywords: | CYP2D6 Polymorphism Real-time PCR cytochrome P450 2D6 fluorescent dye allele article controlled study fluorescence gene frequency gene identification gene mutation genotype heterozygote homozygote human normal human priority journal reverse transcription polymerase chain reaction Turkey (republic) Cytochrome P-450 CYP2D6 Gene Frequency Genetics, Population Humans Polymorphism, Genetic Reverse Transcriptase Polymerase Chain Reaction Turkey |
Abstract: | The frequency of functionally important mutations and alleles of the gene coding for CYP2D6 shows wide ethnic variations. The present study aimed to determine the most common mutated allele CYP2D6*4 gene in a Turkish population of 100 unrelated subjects, by using real-time PCR with fluorescent probe. CYP2D6*4 allele was not detected in 62 subjects (62%). Among the remaining 38 subjects (38%), 4 (4%) were carriers of two *4 alleles, being homozygous for CYP2D6 and genotyped as CYP2D6*4/*4. 34 subjects (34%) were carriers of one *4 allele, being heterozygous for CYP2D6*4. The frequency of allele *4 was 0.21. These data indicate that 4% of the Turkish individuals living in the city of Bursa are carriers of two nonfunctional mutated alleles *4, being homozygous for CYP2D6*4. It is clinically important to be able to identify those individuals who are likely to have altered pharmacokinetics for CYP2D6 substrates in order to avoid adverse drug reactions. Copyright © 2007 S. Karger AG. | URI: | https://hdl.handle.net/11499/4240 https://doi.org/10.1159/000100959 |
ISSN: | 0031-7012 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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