Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4288
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dc.contributor.authorIwasaki, K.-
dc.contributor.authorEgashira, N.-
dc.contributor.authorTakagaki, Y.-
dc.contributor.authorYoshimitsu, Y.-
dc.contributor.authorHatip-Al-Khatib, İzzettin-
dc.contributor.authorMishima, K.-
dc.contributor.authorFujiwara, M.-
dc.date.accessioned2019-08-16T11:33:13Z
dc.date.available2019-08-16T11:33:13Z
dc.date.issued2007-
dc.identifier.issn0918-6158-
dc.identifier.urihttps://hdl.handle.net/11499/4288-
dc.identifier.urihttps://doi.org/10.1248/bpb.30.698-
dc.description.abstractIn the present study, we examined the effects of nilvadipine and amlodipine, both dihydropyridine-derivative calcium antagonists, on the impairment of spatial memory induced by a combination of ischemia and ß-amyloid (Aß). Nilvadipine (3.2 mg/kg, i.p.) significantly prevented the impairment of spatial memory and neuronal apoptosis in this model. By contrast, amlodipine had no effect on this impairment of spatial memory. These findings suggest that nilvadipine may prevent impairment of spatial memory by inhibiting neuronal apoptosis; this drug might therefore be useful for the prevention of the progression to dementia in Alzheimer's disease (AD). © 2007 Pharmaceutical Society of Japan.en_US
dc.language.isoenen_US
dc.relation.ispartofBiological and Pharmaceutical Bulletinen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectß-amyloiden_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectApoptosisen_US
dc.subjectIschemiaen_US
dc.subjectNilvadipineen_US
dc.subjectSpatial memoryen_US
dc.subjectamlodipineen_US
dc.subjectamyloid beta proteinen_US
dc.subjectnilvadipineen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectarticleen_US
dc.subjectbrain ischemiaen_US
dc.subjectdrug mechanismen_US
dc.subjecthippocampusen_US
dc.subjectmaleen_US
dc.subjectmemory disorderen_US
dc.subjectnerve cell necrosisen_US
dc.subjectnonhumanen_US
dc.subjectraten_US
dc.subjectspatial memoryen_US
dc.subjectAmyloid beta-Proteinen_US
dc.subjectAnimalsen_US
dc.subjectBrain Ischemiaen_US
dc.subjectCalcium Channel Blockersen_US
dc.subjectMaleen_US
dc.subjectMaze Learningen_US
dc.subjectMemory Disordersen_US
dc.subjectNeuronsen_US
dc.subjectNifedipineen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.subjectSpace Perceptionen_US
dc.titleNilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with ß-amyloid in ratsen_US
dc.typeArticleen_US
dc.identifier.volume30en_US
dc.identifier.issue4en_US
dc.identifier.startpage698
dc.identifier.startpage698en_US
dc.identifier.endpage701en_US
dc.authorid0000-0002-9127-6779-
dc.identifier.doi10.1248/bpb.30.698-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid17409505en_US
dc.identifier.scopus2-s2.0-34147128293en_US
dc.identifier.wosWOS:000246382600016en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale University-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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