Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4301
Title: Histological and ultrastructural evidence for protective effects on aluminium-induced kidney damage by intraperitoneal administration of ?-tocopherol
Authors: Kutlubay, Recep.
Oguz, Emin Oğuzhan.
Güven, C.
Can, B.
Sınık, Zafer.
Tuncay, Ömer Levent.
Keywords: ?-Tocopherol
Aluminium
Kidney
Nephrotoxicity
Vitamin E
alpha tocopherol
aluminum
asetat
unclassified drug
abdomen
acute toxicity
aluminum overload
animal experiment
animal model
animal tissue
article
basophil
Bowman capsule
cell ultrastructure
controlled study
cytoplasm
drug effect
glomerulopathy
histology
kidney hemorrhage
kidney injury
kidney proximal tubule
kidney tubule cell
male
microscopy
nonhuman
renal protection
treatment outcome
alpha-Tocopherol
Alum Compounds
Animals
Antioxidants
Disease Models, Animal
Drug Antagonism
Drug Therapy, Combination
Injections, Intraperitoneal
Kidney Diseases
Male
Microscopy, Electron, Transmission
Nephrons
Rats
Rats, Wistar
Rattus
Abstract: The nephrotoxic actions of aluminium (Al) arise from its accumulation in the kidneys, with the resultant degeneration of the renal tubular cells. It has been suggested that Al generates reactive oxygen species that cause the oxidative deterioration of cellular lipids, proteins, and DNA. To test this hypothesis, we have here investigated the potential for a protective role of ?-tocopherol (vitamin E) during short-term exposure of rats to Al. Al was administered intraperitoneally either alone or in combination with vitamin E at a different point of abdomen, and the alterations in the kidney tissue were analyzed histologically. The results reveal that significant light microscopical and ultrastructural damage is caused by Al, whereas with the immediate coadministration of vitamin E, there is a protective effect against this damage to the kidney tissue. In Al-alone group, the glomeruli and proximal tubuli and the Bowman capsules had swellings, adherence, hemorrhage, increase in mesengial matrix, and marked interstitial tissue fibrosis, indicating severe damage. In the Al and vitamin E immediate coinjected group, renal tubule cells were almost of a normal appearance. A slight stenosis was seen in the capsular area in the Malpighi corpuscules. The tubular organization and the cytoplasmic basophilia were also much the same as in the control group, with the lumen clearly visible in most of the cortical tubuli. The results highlight the need to reduce exposure to Al, with particular attention being paid to the known sources of Al. At the same time, the maintenance of a diet that is rich in vitamin E should be beneficial in the alleviation of Al toxicity. Copyright © American College of Toxicology.
URI: https://hdl.handle.net/11499/4301
https://doi.org/10.1080/10915810701221173
ISSN: 1091-5818
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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