Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4329
Title: Antioxidant and chemoprotective properties of Momordica charantia L. (bitter melon) fruit extract
Authors: Semiz, Aslı.
Sen, Alaattin.
Keywords: Antioxidant enzymes
Chemoprotection
Cytochrome P450
Glutathione S-transferases
Momordica charantia
catalase
cytochrome P450
glutathione peroxidase
glutathione transferase
Momordica charantia extract
superoxide dismutase
animal cell
animal experiment
animal model
animal tissue
antioxidant activity
article
catalysis
chemoprophylaxis
controlled study
cytosol
drug effect
enzyme activity
kidney
liver
liver microsome
liver protection
liver toxicity
lung
male
nonhuman
rat
Animalia
Cucumis
Rattus
Rattus norvegicus
Abstract: Momordica charantia, commonly known as bitter melon, is used as a vegetable in number of countries. Extracts of M. charantia plant, fruit pulp, and seed have been reported to have a wide medicinal use in the traditional medical systems, most often as hypoglycemic and anti-diabetic agents. We have studied the effect of M. charantia, collected from Kazdaglari (Mount Ida) in Balikesir, fruit extract on glutathione S-transferases (GSTs), cytochrome P450s (CYPs), and antioxidant enzymes in rats. Male Wistar rats, aged 12 weeks and weighing 200-250 g, were given 200 mg M. charantia fruit extract per kg body weight, i.p., for four consecutive days. At the end of the experimental period, the animals were sacrificed, and liver, kidney, and lung were isolated. Our results have indicated significant increase in especially hepatic antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities. The strongest increase (about 9-fold) was observed in GPx activities while about 2 to 5-fold increases were observed in SOD and CAT. M. charantia fruit extract also exhibited hepatoprotective effects in CCl4-intoxicated rats. In addition, about 50% increase was also noted with hepatic cytosolic GSTs. On the other hand, treatments of rats with M. charantia significantly reduced both ethoxyresorufin O-deethylase (EROD) and methoxyresorufin O-deethylase (MROD) activities in rat liver microsomes, which are known to be catalyzed by CYP1A isoforms These results suggest that the M. charantia fruit extract possesses the anti-oxidant effects besides having protective activities in rats. © 2007 Academic Journals.
URI: https://hdl.handle.net/11499/4329
ISSN: 1684-5315
Appears in Collections:Fen-Edebiyat Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

SCOPUSTM   
Citations

78
checked on Oct 13, 2024

WEB OF SCIENCETM
Citations

65
checked on Oct 31, 2024

Page view(s)

54
checked on Aug 24, 2024

Google ScholarTM

Check





Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.