Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/43630
Title: Hippocampal volume reduction after chemotherapy assessed by brain MRI: a cause of chemobrain in cancer patients
Other Titles: Kemoterapi sonrası hipokampüs hacmindeki azalmanın beyin MRG ile değerlendirilmesi:kanser hastalarında kemobeyinin bir sebebi
Authors: Herek, Duygu
Doğu, Gamze Gököz
Özdemir, Mehmet Bülent
Yapar Taşköylü, Burcu
Çakıroğlu, Umut
Doğu, Yurdaer
Yaren, Arzu
Keywords: Anatomi ve Morfoloji;Anestezi;Biyokimya ve Moleküler Biyoloji;Biyofizik;Kalp ve Kalp Damar Sistemi;Klinik Nöroloji;Dermatoloji;Acil Tıp;Endokrinoloji ve Metabolizma;Gastroenteroloji ve Hepatoloji;Hematoloji;Enfeksiyon Hastalıkları;Adli Tıp;Mikrobiyoloji;Kadın Hastalıkları ve Doğum;Onkoloji;Göz Hastalıkları;Ortopedi;Kulak, Burun, Boğaz;Patoloji;Pediatri;Fizyoloji;Psikiyatri;Halk ve Çevre Sağlığı;Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme;Rehabilitasyon;Romatoloji;Cerrahi;Üroloji ve Nefroloji
Abstract: Purpose:Cancer treatment (chemotherapy) affects various neural parts of the brain which results in cognitiveimpairments as problems in working memory, concentration, speed of processing and responding, and speech.This condition is called “chemobrain”. The aim of this study is to establish whether any change exists in thevolume of certain brain parts before and after chemotherapy that might play a role in chemobrain by means ofmagnetic resonance imaging (MRI).Materials and methods: Eleven patients with various cancers underwent cranial MRI before and afterchemotherapy. 3-dimensional reconstruction from coronal 2 dimensional images were obtained by SURFDriverprogram. Volume calculations of cerebrum, cerebellum, ventricles, right and left hippocampus were done byCavalieri method.Results:According to measurements there was a statistically significant difference only in the volumes of rightand left hippocampus before and after chemotherapy (p<0.05). The volumes of the hippocampus on both sidesdecreased after chemotherapy.Conclusion:This study revealed significant volume changes in the hippocampus of cancer patients afterchemotherapy. We suggest that this volume reduction in hippocampal regions might be the explanation ofchemobrain seen in cancer patient during and after chemotherapy
URI: https://hdl.handle.net/11499/43630
https://doi.org/10.5505/ptd.2017.60565
ISSN: 1309-9833
1308-0865
Appears in Collections:Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection

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