Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4373
Title: Effects of CPAP on left ventricular structure and myocardial performance index in male patients with obstructive sleep apnoea
Authors: Dursunoğlu, Neşe.
Dursunoğlu, Dursun.
Özkurt, Sibel.
Kuru, Ömür.
Gür, Şükrü.
Kiter, Göksel.
Evyapan, Fatma.
Keywords: Continuous positive airway pressure
Left ventricular dysfunction
Left ventricular structure
Myocardial performance index
Obstructive sleep apnoea
adult
article
body mass
clinical article
controlled study
disease severity
Doppler echocardiography
heart failure
heart function
heart left ventricle
heart left ventricle ejection time
heart muscle relaxation
heart performance
heart ventricle contraction
heart ventricle septum
heart ventricle wall
human
hypertension
M mode echocardiography
male
patient compliance
patient selection
polysomnography
positive end expiratory pressure
priority journal
sleep apnea syndrome
Body Mass Index
Continuous Positive Airway Pressure
Disorders of Excessive Somnolence
Electrocardiography
Humans
Male
Middle Aged
Myocardium
Polysomnography
Respiratory Function Tests
Severity of Illness Index
Sleep Apnea, Obstructive
Ventricular Dysfunction, Left
Abstract: Background: Obstructive sleep apnoea (OSA) has the potential to cause heart failure. We aimed to determine the effects of nasal continuous positive airway pressure (CPAP) therapy on left ventricular structure and myocardial performance index (MPI) in severe OSA patients. Methods: Sixty-seven subjects without any cardiac or pulmonary disease had overnight polysomnography and echocardiography. In 33 males with severe OSA, thickness of interventricular septum (IVS) and posterior wall (LVPW) were measured by M-mode. Left ventricular MPI was calculated as (isovolumic contraction time + isovolumic relaxation time)/aortic ejection time by Doppler. Results: Eight males were non-compliant with CPAP. Mean age was 47.9±8.2 years, and 20 of 25 patients (80.0%) were hypertensive. Patients had high body mass index (BMI: 31.0±3.9 kg/m2), but there was no change in BMI from baseline after 6 months. Thickness of IVS (11.0±1.1 mm) and LVPW (11.0±1.0 mm) at baseline were significantly decreased after 6 months of CPAP therapy (10.5±0.9 mm, P < 0.001 and 10.4±0.7 mm, P < 0.0001, respectively). Left ventricular MPI (60.1±13.8%) significantly decreased (53.0±10.7%, P < 0.0001) after CPAP usage. Conclusions: In male patients with severe OSA, CPAP therapy significantly decreases left ventricular wall thickness and improves global function even with 6 months of usage. © 2006 Elsevier B.V. All rights reserved.
URI: https://hdl.handle.net/11499/4373
https://doi.org/10.1016/j.sleep.2006.04.007
ISSN: 1389-9457
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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