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https://hdl.handle.net/11499/4374
Title: | Anticandidal activity of Pseudomonas aeruginosa strains isolated from clinical specimens | Authors: | Kaleli, İlknur. Cevahir, Nural. Demir, Melek. Yıldırım, Umut. Şahin, Rasim. |
Keywords: | Anticandidal activity Candida species Pseudomonas aeruginosa agar pyocyanine animal model antifungal activity article bacterial strain bacterium isolate bacterium isolation Candida albicans Candida krusei Candida parapsilosis Candida tropicalis fungus isolation in vitro study in vivo study inhibition kinetics intensive care mouse nonhuman patient care priority journal tissue section yeast Animals Antibiosis Candida Candidiasis Culture Media Dermatomycoses Humans Mice Mice, Inbred BALB C Pseudomonas Infections Issatchenkia orientalis Pseudomonas |
Abstract: | Pseudomonads represent the major group of non-differentiating microorganisms that produce antibiotics. The antibiotic substances produced by this group of organisms are pyocyanin, pyrolnitrin and pseudomonic acid. This study was designed to investigate the in vivo and in vitro anticandidal activity of Pseudomonas aeruginosa strains against Candida species. Forty-four P. aeruginosa strains isolated from various specimens of intensive care patients were included in the study. All P. aeruginosa strains have pyocyanin pigment. Candida albicans ATCC 10231, Candida parapsilosis ATCC 22019, Candida krusei ATCC 6258 and a clinical isolate of Candida tropicalis were used to measure the anticandidal activity of Pseudomonas strains by Kerr's method. The total inhibition rates obtained by using blood agar of C. albicans, C. parapsilosis, C. krusei and C. tropicalis were 41%, 34%, 34% and 25% respectively. When Sabouraud dextrose agar (SDA) was used, the rates were detected as 45%, 39%, 48% and 25% respectively. In the mouse model of concomitant subcutaneous infection with Candida species and P. aeruginosa no yeast were recovered from skin cultures despite 100% detection of P. aeruginosa. Pseudomonas aeruginosa strains isolated from intensive care patients showed anticandidal activity against the Candida species in the present study and this point may be important in the following and treatment of patients. © 2006 Blackwell Publishing Ltd. | URI: | https://hdl.handle.net/11499/4374 https://doi.org/10.1111/j.1439-0507.2006.01322.x |
ISSN: | 0933-7407 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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