Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4386
Title: Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene in patients with breast cancer and effects on prognostic factors
Authors: Yaren, Arzu
Turgut, S.
Kursunluoglu, R.
Oztop, I.
Turgut, G.
Değirmencioğlu, Serkan
Kelten, C.
Keywords: Angiotensin-converting enzyyme gene polymorphism
Breast cancer
Prognostic factors
dipeptidyl carboxypeptidase
epidermal growth factor receptor 2
article
blood
breast cancer
cancer patient
controlled study
DNA polymorphism
female
gene deletion
gene insertion
gene overexpression
genotype
human
major clinical study
medical record
polymerase chain reaction
Publisher: BMJ Publishing Group
Abstract: The aims of the present study were to investigate the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in breast cancer patients and the association between ACE genotypes and clinicopathologic features, as well as their effects on prognosis. We assessed the I/D polymophism of the ACE gene by using polymerase chain reaction from peripheral blood in breast cancer and healthy age-matched women. The clinicopathologic parameters of breast cancer patients were obtained from medical records. Of the 57 patients, 31 (54.4%) had DD, 24 (42.1%) had ID, and 2 (3.5%) had II genotypes. In control subjects, 33 (63.5%) had DD, 12 (23.1%) had ID, and 7 (13.4%) had II genotypes. The ID genotype was seen more commonly in breast cancer patients (p = .03). When the combination of ID and II genotypes was used as a reference group, the DD genotype was associated with negative hormone receptor status (p = .003), tumor size (p = .054), and lymph node involvement (p = .07) but not histologic high grade and c-erb B2 overexpression. These results suggest that the DD genotype may accompany poor prognostic factors and influence the tumor course.
URI: https://hdl.handle.net/11499/4386
https://doi.org/10.2310/6650.2007.00006
ISSN: 1708-8267
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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