Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4392
Title: Transmission electron microscopy study of the effects of cadmium and copper on fetal rat liver tissue
Authors: Oguz, Emin Oğuzhan.
Abban Mete, Gülçin
Kutlubay, Recep.
Turgut, Sebahat.
Enli, Yaşar.
Erdogan, D.
Keywords: Cadmium
Copper
Electron microscopy
Liver toxicity
Rat
cadmium chloride
copper sulfate
animal cell
animal experiment
animal tissue
article
controlled study
cytotoxicity
endoplasmic reticulum
extracellular matrix
female
fetus
histology
liver cell
liver toxicity
mitochondrial toxicity
nonhuman
rat
ribosome
tissue degeneration
transmission electron microscopy
Animalia
Rattus
Publisher: Humana Press
Abstract: During the entire period of their pregnancies, three groups of adult pregnant Wistar albino rats were provided with tap water (control; group I) or with tap water containing 10 mg/kg CdCl2 (group II) or 10 mg/kg CdCl2 plus 10 mg/kg CuSO4 (group III). At term, the animals were sacrificed and the fetal livers were removed and examined under electron microscopy. The liver tissue of the fetuses in maternal groups II and III showed degenerative changes to their hepatocytes. In group II, the smooth endoplasmic reticulum tubules showed dilatation, and the mitochondria showed a dense matrix. In group III, some mitochondrial degeneration was also seen, with a diluted matrix and mitochondrial dilatation. There were also more heterochromatic nuclei and an increased number of ribosomes. None of these histopathological changes were present in the fetal liver samples from the maternal group I control animals. © Copyright 2007 by Humana Press Inc. All rights of any nature, whatsoever, reserved.
URI: https://hdl.handle.net/11499/4392
https://doi.org/10.1007/BF02686024
ISSN: 0163-4984
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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