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https://hdl.handle.net/11499/4394
Title: | Severe pulmonary haemorrhage accompanying hepatorenal failure in fulminant leptospirosis | Authors: | Dursun, Belda. Bostan, F. Artac, M. Varan, H.I. Suleymanlar, G. |
Keywords: | clarithromycin fresh frozen plasma inotropic agent methylprednisolone sultamicillin adult article artificial ventilation case report electrocardiogram hemodialysis hepatorenal syndrome human laboratory test leptospirosis lung hemorrhage male physical examination plasmapheresis priority journal pulmonary hypertension thorax radiography urinalysis |
Publisher: | Blackwell Publishing Ltd | Abstract: | Leptospirosis is a re-emerging spirochetal zoonosis with a worldwide distribution affecting both animals and humans. The clinical syndromes may vary from a subclinical infection to a severe illness. Although it may potentially have a fulminant and fatal course, leptospirosis usually remains as an underdiagnosed cause of multiorgan failure. In this study, we report a patient with leptospirosis who presented with a fulminant course of diffuse alveolar haemorrhage and hepatorenal failure. His clinical condition deteriorated, despite appropriate antibiotic therapy and haemodialysis. However, he showed prompt clinical improvement when corticosteroids and plasma exchange were instituted in addition to the original therapy. We conclude that leptospirosis should be considered in any case presenting with pulmonary haemorrhage and hepatorenal failure. Plasma exchange and corticosteroids may be a choice of treatment in selected patients unresponsive to conventional therapy. Potential benefits of plasma exchange and corticosteroids may be based on a toxin- and/or cytokine-mediated pathogenesis of the disease. © 2007 The Authors Journal compilation 2007 Blackwell Publishing Ltd. | URI: | https://hdl.handle.net/11499/4394 https://doi.org/10.1111/j.1742-1241.2006.00638.x |
ISSN: | 1368-5031 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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