Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/4398
Title: | The prevalence, aetiological agents and therapy of onychomycosis in patients with psoriasis: A prospective controlled trial | Authors: | Kaçar, Nida Ergin, Şeniz Ergin, Çağrı Erdogan, Berna Şanlı Kaleli, İlknur |
Keywords: | terbinafine adolescent adult aged Alternaria article Candida guilliermondii Candida parapsilosis clinical trial controlled clinical trial controlled study dermatophyte disease predisposition drug efficacy drug response female follow up fungus growth human major clinical study male mould onychomycosis priority journal psoriasis risk factor Saccharomyces cerevisiae school child treatment outcome Trichophyton rubrum Adolescent Adult Aged Antifungal Agents Case-Control Studies Child Female Foot Dermatoses Hand Dermatoses Humans Longitudinal Studies Male Middle Aged Mitosporic Fungi Naphthalenes Onychomycosis Prevalence Prospective Studies Psoriasis |
Abstract: | Background. Nail involvement morphologically resembling onychomycosis frequently accompanies psoriatic lesions. The role of psoriasis as a predisposing factor for onychomycosis and the possible influence of psoriasis on responsiveness of onychomycosis to treatment are controversial. Aim. To investigate the frequency of onychomycosis, the aetiological agents responsible for it, and the efficacy of terbinafine 250 mg/day in patients with psoriasis compared with controls in order to reveal the role of psoriatic process on fungal growth. Methods. Over a 1-year period, 168 patients with psoriasis and 164 nonpsoriatic controls were recruited. In the case of clinically suspected of fungal infection, further mycological investigations were performed. Systemic terbinafine therapy 250 mg daily for 12 weeks was administered to the patients with onychomycosis. Patients were followed up clinically and mycologically for 24 weeks. Results. Onychomycosis was diagnosed in 22 patients with psoriasis (13.1% of the psoriasis group, which constituted 28.6% of patients with suspicion of onychomycosis) and 13 controls (7.9% of control group; 40.6% of controls with suspicion of onychomycosis). The prevalence rates of onychomycosis were similar in both groups. The most commonly isolated fungi were dermatophytes in the psoriasis group and nondermatophytic moulds in controls. Dermatophytes were more common in psoriatic than control nails (P = 0.02). All patients in each group were cured at the end of the therapy. Conclusion. It seems that nail psoriasis constitutes a risk factor not for onychomycosis, but specifically for dermatophytic nail infections. Because of the similar therapeutic results in each group, different antifungal treatment protocols may not be needed in psoriasis. However, to confirm this, new comprehensive studies are necessary. © 2007 Blackwell Publishing Ltd. | URI: | https://hdl.handle.net/11499/4398 https://doi.org/10.1111/j.1365-2230.2006.02215.x |
ISSN: | 0307-6938 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Show full item record
CORE Recommender
SCOPUSTM
Citations
43
checked on Dec 21, 2024
WEB OF SCIENCETM
Citations
34
checked on Dec 18, 2024
Page view(s)
42
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.