Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/44019
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kutluana, Ufuk | - |
dc.contributor.author | Oruç, Nevin | - |
dc.contributor.author | Dinçer Tekekoğlu, Selma | - |
dc.contributor.author | Çallı Demirkan, Neşe | - |
dc.contributor.author | Akdağ, Beyza | - |
dc.contributor.author | Yılmaz, Mustafa | - |
dc.contributor.author | Yönetçi, Nadir | - |
dc.contributor.author | Özütemir, Ömer | - |
dc.date.accessioned | 2022-05-17T12:37:23Z | - |
dc.date.available | 2022-05-17T12:37:23Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1309-9833 | - |
dc.identifier.issn | 1308-0865 | - |
dc.identifier.uri | https://hdl.handle.net/11499/44019 | - |
dc.identifier.uri | https://doi.org/10.31362/patd.451731 | - |
dc.description.abstract | Purpose: Long-term clinical use of methotrexate is connected with a raised risk of liver injury and fibrosis.Leflunomide is a disease-modifying drug. Leflunomide has a powerful inhibitory effect on nuclear factor kappaB activation. Leflunomide also presents antioxidant activity. In this experimental study, we aimed to investigatethe effects of leflunomide treatment on methotrexate -induced hepatotoxicity.Materials and methods: Thirty-nine rats were divided into 4 groups. A single dose of 20mg/kg methotrexatewas injected intraperitoneally for methotrexate-induced hepatotoxicity. After induction, leflunomide (10 mg/kg)was administered into the stomach for consecutive 5 days. Then, serum samples and homogenated liver tissueswere collected for analyzed serum alanine aminotransferase, alkaline phosphatase, superoxide dismutaseactivity, myeloperoxidase activity, glutathione levels and assessment of histopathology.Results: Leflunomide treatment significantly ameliorated total histopathologic score according to semiquantitativescale compared to the untreated group, (Pathological score 1.1+0.7 versus 5.1+2 respectively, p<0,01).Leflunomide treatment significantly ameliorated Kuppfer cell activation. (Elevation of the activated Kupffercells score were 0.2+0.6 and 2.5+1.01 respectively, p = 0.001). The serum alanine aminotransferase, alkalinephosphatase levels were lower and glutathione levels, myeloperoxidase activity, and superoxide dismutaseactivity were similar between leflunomide treated and untreated methotrexate toxicity groups.Conclusion: Leflunomide treatment ameliorated methotrexate induced liver toxicity in this experimental model. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Pamukkale Tıp Dergisi | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Anatomi ve Morfoloji;Anestezi;Biyokimya ve Moleküler Biyoloji;Biyofizik;Kalp ve Kalp Damar Sistemi;Klinik Nöroloji;Dermatoloji;Acil Tıp;Endokrinoloji ve Metabolizma;Gastroenteroloji ve Hepatoloji;Hematoloji;Enfeksiyon Hastalıkları;Adli Tıp;Mikrobiyoloji;Kadın Hastalıkları ve Doğum;Onkoloji;Göz Hastalıkları;Ortopedi;Kulak, Burun, Boğaz;Patoloji;Pediatri;Fizyoloji;Psikiyatri;Halk ve Çevre Sağlığı;Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme;Rehabilitasyon;Romatoloji;Cerrahi;Üroloji ve Nefroloji | en_US |
dc.title | Can leflunomide prevent methotrexate induced liver toxicity? | en_US |
dc.title.alternative | Leflunomid methotrexat'a bağlı karaciğer toksisitesini önleyebilir mi? | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 321 - 327 | - |
dc.identifier.startpage | 321 | en_US |
dc.identifier.endpage | 327 | en_US |
dc.trdizinedit | $$TRDizinEdit$$ | - |
dc.identifier.doi | 10.31362/patd.451731 | - |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.trdizinid | 325657 | en_US |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
document (2).pdf | 481.75 kB | Adobe PDF | View/Open |
CORE Recommender
Page view(s)
38
checked on May 27, 2024
Download(s)
2
checked on May 27, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.