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https://hdl.handle.net/11499/44279
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DC Field | Value | Language |
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dc.contributor.author | Kandemir, Altay | - |
dc.contributor.author | Çelik, Mustafa | - |
dc.contributor.author | Ünsal, Belkıs | - |
dc.date.accessioned | 2022-05-17T12:39:56Z | |
dc.date.available | 2022-05-17T12:39:56Z | |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1303-6629 | - |
dc.identifier.issn | 2149-0600 | - |
dc.identifier.uri | https://hdl.handle.net/11499/44279 | - |
dc.description.abstract | Background and Aims: Cytokeratin-18 is the known substrate forcaspases, which are encountered during hepatic and pancreatic acinarapoptosis. Studies performed in recent years have indicated thatthe cleavage level of serum cytokeratin-18 (M30 antigen) is correlatedwith hepatic fibrosis and disease severity in both chronic hepatitis Cand non-alcoholic steatohepatitis. It was shown that antiviral therapyin chronic viral hepatitis C patients significantly reduced hepatocellularapoptosis and cytokeratin-18 is accepted as a reliable marker of hepatocyteapoptosis. Our aim was to determine the correlation between thecytokeratin-18 level and treatment response in patients with chronicviral hepatitis C. Materials and Methods: Sixty patients with chronicviral hepatitis C were included in the study. A 48-week course of peginterferon-ribavirintherapy was given to appropriate patients. Hepatitis Cvirus RNA was measured at 0, 12, and 24 weeks at the end of therapyand 72 weeks. In addition, cytokeratin-18 levels were measured at 0,24, and 72 weeks. Results: The mean age of 60 patients was 52±10.9years. While 31 (51.6%) of patients were in the sustained viral responsegroup, 29 (8.4%) of patients were in the non-sustained viral responsegroup. It was determined that while the cytokeratin-18 level at week 0in the sustained viral response group was 243±21, the cytokeratin-18level at week 24 was 115±12 U/L and the difference between the levelof cytokeratin-18 at weeks 0 and 24 were 127±209 U/L (p: .014). Whilethe cytokeratin-18 level at week 0 in the non- sustained viral responsegroup was 270±14; at week 24, the cytokeratin-18 level was 136±19U/L and the difference between cytokeratin-18 levels at weeks 0 and24 was 136±156 U/L (p > .5). At week 72, the cytokeratin-18 level inthe sustained viral response group was 109±38 and the difference betweenweeks 0 and 72 was 134±215 (p < .002). Conclusion: In chronicviral hepatitis C patients, there was a correlation between sustainedviral response and cytokeratin-18, which is a marker of apoptosis.During treatment, it was found that there was a relationship betweensustained viral response and the decrease in cytokeratin-18 levels. Thisfinding indicates that cytokeratin-18 level monitoring may be used as apredictive marker of sustained viral response. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Akademik Gastroenteroloji Dergisi | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Gastroenteroloji ve Hepatoloji | en_US |
dc.title | Changes in serum levels of cytokeratin-18 fragments in patients with chronic hepatitis C under antiviral therapy | en_US |
dc.title.alternative | Kronik hepatit C hastalarında antiviral tedavi ile serum sitokeratin-18 düzeylerinin değişimi | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 28 - 32 | |
dc.identifier.startpage | 28 | en_US |
dc.identifier.endpage | 32 | en_US |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.trdizinid | 298653 | en_US |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection |
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File | Size | Format | |
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Changes in serum levels of cytokeratin.pdf | 93.42 kB | Adobe PDF | View/Open |
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