Retrospective evaluation of brain metastates in lung cancer patients treated with stereotactic radiosurgery alone

Abstract

INTRODUCTION: Due to new systemic treatment modalities, overall survival in lung cancer is increasing.Incidence of brain metastases in lung cancer are more common for this reason. The utilisation of stereotacticradiosurgery for one and oligo (two-four) brain metastases, has provided this treatment strategy as a promttreatment alternative. In this study we aimed to investigate the efficiency of stereotactic radiosurgery in lungcancer patients with brain metastasis, the effectiveness of adding diffusion magnetic resonance imaging (MRI) toconventional MRI for treatment evaluation and the relationship between clinical parameters retrospectively.METHODS: Seventy-nine lung cancer patients treated between January 2016 and December 2017 in our clinicwith stereotactic radiosurgery whose eastern cooperative oncology group (ECOG) performance status were 0-1and had less than 5 brain metastases, has retrsopectively analysed.RESULTS: The median age of patients was 59 years (43-78). Diffusion MRI has provided no more benefit forevaluation of treatment. There was no statistically significant mortality difference between subgroups of smallcell and non small cell lung carcinoma. The presence of extracranial metastases has shortened the overallsurvival time significantly (p=0,042).DISCUSSION AND CONCLUSION: The lung cancer patients with brain metastases have histopathologicaland genetic heterogenity. Multivariate analysis showed the presence of extracranial metastases had onlyunfavorable impact on overall survival in our study.