Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/44869
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dc.contributor.authorYapar Taşköylü, Burcu-
dc.contributor.authorDemiray, Aydın-
dc.contributor.authorDemiray, Atike Gökçen-
dc.contributor.authorGököz Doğu, Gamze-
dc.contributor.authorYaren, Arzu-
dc.contributor.authorDeğirmencioğlu, Serkan-
dc.contributor.authorKaran, Canan-
dc.contributor.authorAkca, Hakan-
dc.contributor.authorBir, Ferda-
dc.contributor.authorErgin, Ahmet-
dc.date.accessioned2022-05-17T12:45:17Z-
dc.date.available2022-05-17T12:45:17Z-
dc.date.issued2020-
dc.identifier.issn2651-4532-
dc.identifier.urihttps://hdl.handle.net/11499/44869-
dc.identifier.urihttps://doi.org/10.37047/jos.2020-76948-
dc.description.abstractObjective:Apoptosis plays a critical role in carcinogenesis. Intracellular proteases known as caspase-9 directly or indirectly playroles inactivating apoptosis. In this study, we aimed to investigate the effect of caspase-9 level in lung skuamous cancer tumor tissues on lymphnode metastasis, clinicopathologic parameters and prognosis. Material and Methods: The study included 50 patients diagnosed with squamous cell lung cancer. The caspase-9 level in the tumor and metastatic lymph nodes was assessed using real time-polymerase chain reaction(RT-PCR) methods. Results: The median age of the patients was 61 years (range, 54-68 years). All patients were men and smokers. Theaverage duration of follow-up was 50.26±39.21 months, and progression-free survival was 26.34±19.50 months. Among 50 patients, 22 (44%)had lymph node metastasis. The caspase-9 level was studied in tumors with and without lymph node metastasis. Moreover, the caspase-9 levels in tumors with lymph node metastasis were statistically and significantly lower than tumors without lymph node metastasis (p<0.001). Thecaspase-9 level decreased as the stage increased (p<0.001). In the presence of angiolymphatic invasion and poorly differentiated tumor tissue, a low level of caspase-9 was identified. Conclusion: The caspase-9 level decreased with increasing stage and the presence of lymphnode metastasis. No statistically significant association was detected between caspase-9 and survival. A literature review revealed that nostudies have evaluated the correlation between caspase-9 in the squamous cell subtype, clinicopathological parameters, and survival. Extensive studies involving a significant number of patients are required to determine the prognostic and predictive significance of the caspase-9level in our population.en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of oncological sciencesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleExpression of Caspase-9 in Early and Locally Advanced Stage Squamous Cell Lung Canceren_US
dc.typeArticleen_US
dc.identifier.volume6en_US
dc.identifier.issue3en_US
dc.identifier.startpage147 - 152-
dc.identifier.startpage147en_US
dc.identifier.endpage152en_US
dc.identifier.doi10.37047/jos.2020-76948-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopus2-s2.0-85105688084en_US
dc.identifier.trdizinid423344en_US
dc.identifier.scopusquality--
dc.ownerPamukkale University-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.openairetypeArticle-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
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