Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4513
Title: Topical versus systemic vancomycin for deep sternal wound infection caused by methicillin-resistant Staphylococcus aureus in a rodent experimental model
Authors: Özcan, Ali Vefa
Demir, Melek
Önem, Gökhan
Gökşin, İbrahim
Baltalarlı, Ahmet
Topkara, V.K.
Kaleli, İlknur
Keywords: Anti-bacterial agents/therapeutic use
Drug resistance, bacterial
Mediastinitis/prevention & control
Postoperative care
Rats
Staphylococcal infections/drug therapy/prevention & control
Sternum/surgery
ketamine
vancomycin
vankomisin
xylazine
animal experiment
animal model
article
bacterial growth
bacterium isolation
controlled study
drug activity
drug efficacy
experimental model
methicillin resistant Staphylococcus aureus
nonhuman
rat
sternotomy
sternum
treatment outcome
wound infection
Administration, Topical
Animals
Anti-Bacterial Agents
Infusions, Intravenous
Male
Methicillin Resistance
Rats, Wistar
Staphylococcal Infections
Staphylococcus aureus
Stem Cells
Sternum
Surgical Wound Infection
Vancomycin
Abstract: In 37 Wistar albino rats, we investigated the effects of topical vancomycin on deep sternal wound infection caused by methicillin-resistant Staphylococcus aureus. Partial median sternotomy was performed under sterile conditions. Group I (n=6) was the sham, and group II (n=7) was the control. Group III (n=8) received topical vancomycin, group IV (n=8) received systemic vancomycin, and group V (n=8) received topical and systemic vancomycin (combined). Rats in groups II through V were inoculated with 0.5 mL × 108 CFU/mL methicillin-resistant S. aureus in the mediastinum and sternum. No medication was given to groups I and II. Twenty-four hours after surgery, 40 mg/kg/day vancomycin was given topically in group III; systemically in group IV; and topically and systemically in group V. After 7 days, smear samples from the mediastinum and tissue cultures from the sternum were obtained. We found 5.00 ± 0 CFU/mL microorganisms in the mediastinum in group II, 1.90 ± 1.70 in group III, 3.33 ± 0.48 in group IV, and 1.70 ± 1.08 in group V. The quantity of microorganisms per gram of tissue in the sternum was 7.36 ± 0.23 in group II, 6.01 ± 0.33 in group III, 5.81 ± 0.81 in group IV, and 3.99 ± 2.47 in group V. The quantity of microorganisms was less in the 3 treatment groups than in the control group (P <0.05). We conclude that topical plus systemic vancomycin treatment might be more effective in patients with deep sternal wound infections caused by methicillin-resistant S. aureus. © 2006 by the Texas Heart® Institute.
URI: https://hdl.handle.net/11499/4513
ISSN: 0730-2347
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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