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https://hdl.handle.net/11499/4513
Title: | Topical versus systemic vancomycin for deep sternal wound infection caused by methicillin-resistant Staphylococcus aureus in a rodent experimental model | Authors: | Özcan, Ali Vefa Demir, Melek Önem, Gökhan Gökşin, İbrahim Baltalarlı, Ahmet Topkara, V.K. Kaleli, İlknur |
Keywords: | Anti-bacterial agents/therapeutic use Drug resistance, bacterial Mediastinitis/prevention & control Postoperative care Rats Staphylococcal infections/drug therapy/prevention & control Sternum/surgery ketamine vancomycin vankomisin xylazine animal experiment animal model article bacterial growth bacterium isolation controlled study drug activity drug efficacy experimental model methicillin resistant Staphylococcus aureus nonhuman rat sternotomy sternum treatment outcome wound infection Administration, Topical Animals Anti-Bacterial Agents Infusions, Intravenous Male Methicillin Resistance Rats, Wistar Staphylococcal Infections Staphylococcus aureus Stem Cells Sternum Surgical Wound Infection Vancomycin |
Abstract: | In 37 Wistar albino rats, we investigated the effects of topical vancomycin on deep sternal wound infection caused by methicillin-resistant Staphylococcus aureus. Partial median sternotomy was performed under sterile conditions. Group I (n=6) was the sham, and group II (n=7) was the control. Group III (n=8) received topical vancomycin, group IV (n=8) received systemic vancomycin, and group V (n=8) received topical and systemic vancomycin (combined). Rats in groups II through V were inoculated with 0.5 mL × 108 CFU/mL methicillin-resistant S. aureus in the mediastinum and sternum. No medication was given to groups I and II. Twenty-four hours after surgery, 40 mg/kg/day vancomycin was given topically in group III; systemically in group IV; and topically and systemically in group V. After 7 days, smear samples from the mediastinum and tissue cultures from the sternum were obtained. We found 5.00 ± 0 CFU/mL microorganisms in the mediastinum in group II, 1.90 ± 1.70 in group III, 3.33 ± 0.48 in group IV, and 1.70 ± 1.08 in group V. The quantity of microorganisms per gram of tissue in the sternum was 7.36 ± 0.23 in group II, 6.01 ± 0.33 in group III, 5.81 ± 0.81 in group IV, and 3.99 ± 2.47 in group V. The quantity of microorganisms was less in the 3 treatment groups than in the control group (P <0.05). We conclude that topical plus systemic vancomycin treatment might be more effective in patients with deep sternal wound infections caused by methicillin-resistant S. aureus. © 2006 by the Texas Heart® Institute. | URI: | https://hdl.handle.net/11499/4513 | ISSN: | 0730-2347 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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